Parvizi Arman, Haddadi Soudabeh, Akbari Maryam, Akbarpour Maliheh, Taghipour Rudsari Fatemeh, Kazemnezhad Leyli Ehsan
Department of Anesthesiology, Anesthesia Research Center, Al-Zahra Medical-Educational Center, Guilan University of Medical Sciences, Rasht, Iran.
Department of Otolaryngology and Head and Neck Surgery Otorhinolaryngology Research Center, Guilan Universty of Medical Sciences, Rasht, Iran.
Anesth Pain Med. 2023 Jan 5;12(6):e127262. doi: 10.5812/aapm-127262. eCollection 2022 Dec.
Postoperative sore throat (POST) syndrome commonly occurs after general anesthesia and surgery, leading to patient discomfort.
This essay aims to assess the effect of using zinc-impregnated packs on sore throat and post-op nausea and vomiting after general anesthesia among patients undergoing septorhinoplasty.
The sampling method was based on the patients' gradual referral, and encompassing was performed using the randomized block. The participants were divided into four groups by random allocation technique considering the type of pharyngeal packs: (1) normal saline-impregnated vibril, (2) normal saline-impregnated gauze, (3) zinc solution-impregnated vibril, (4) zinc solution-impregnated gauze. The sample size required to compare the incidence of sore throat after septorhinoplasty was determined to be 220 patients.
Out of 220 patients undergoing septorhinoplasty, 55 were assigned to each group. According to A.S.A., most of the patients belonged to class I. In total, 5.5% and 15.1% had a history of gastroesophageal reflux disease (GERD) and smoking, respectively. There was no statistically significant difference among the four groups in terms of the sore throat immediately (P = 0.227), two h (P = 0.527), four h (P = 0.505), six h (P = 0.564) and 24 h (P = 0.481) after surgery. Results of pairwise comparison revealed no statistical difference between the groups receiving zinc and other groups. There was no statistically significant difference between the four groups in terms of the severity of sore throat. A statistically significant difference was observed between the gauze + zinc and gauze + normal saline groups regarding the incidence of nausea two hours after surgery (P = 0.0045).
This study showed that applying topical zinc to the pack had no significant effect on reducing sore throat. However, there was a significant difference between the groups receiving zinc solution-impregnated gauze and normal saline-impregnated gauze in terms of the severity of nausea two h after surgery.
术后咽喉痛（POST）综合征常在全身麻醉和手术后出现，给患者带来不适。
本文旨在评估使用含锌敷料对鼻中隔成形术患者全身麻醉后咽喉痛及术后恶心呕吐的影响。
抽样方法基于患者的逐步转诊，并采用随机区组进行纳入。根据咽部敷料类型，通过随机分配技术将参与者分为四组：（1）生理盐水浸渍的颤音膜，（2）生理盐水浸渍的纱布，（3）锌溶液浸渍的颤音膜，（4）锌溶液浸渍的纱布。确定比较鼻中隔成形术后咽喉痛发生率所需的样本量为220例患者。
220例接受鼻中隔成形术的患者中，每组分配55例。根据美国麻醉医师协会（A.S.A.）分级，大多数患者属于I级。总体而言，分别有5.5%和15.1%的患者有胃食管反流病（GERD）和吸烟史。四组在术后即刻（P = 0.227）、2小时（P = 0.527）、4小时（P = 0.505）、6小时（P = 0.564）和24小时（P = 0.481）的咽喉痛方面无统计学显著差异。两两比较结果显示，接受锌治疗的组与其他组之间无统计学差异。四组在咽喉痛严重程度方面无统计学显著差异。在术后2小时恶心发生率方面，纱布+锌组和纱布+生理盐水组之间存在统计学显著差异（P = 0.0045）。
本研究表明，在敷料上局部应用锌对减轻咽喉痛无显著效果。然而，在术后2小时恶心严重程度方面，接受锌溶液浸渍纱布组和生理盐水浸渍纱布组之间存在显著差异。
