Farhang Borzoo, Grondin Lydia
From the Department of Anesthesiology, University of Vermont College of Medicine, Burlington, Vermont.
Anesth Analg. 2018 Jan;126(1):78-83. doi: 10.1213/ANE.0000000000002494.
Postoperative sore throat (POST) is commonly seen after endotracheal intubation, and oral zinc prevents oral mucositis associated with chemotherapy. This study is designed to evaluate the effects of administration of zinc lozenges on POST.
Seventy-nine patients undergoing low- or moderate-risk surgery with endotracheal intubation were randomly assigned into 2 groups: Control group received placebo and zinc group received 40-mg zinc lozenges 30 minutes preoperatively. Patients were assessed for incidence and severity (4-point scale, 0-3) of POST at 0, 2, 4, and 24 hours postoperatively. The primary outcome was incidence of POST at 4 hours after surgery. The secondary outcomes were the incidence of POST at 0, 2, and 24 hours and the severity of POST.
At 4 hours, there was a significantly lower incidence of POST in the zinc group, 7%, than the control group, 29% (P = .046). The incidence of POST at 0 hour was 0% in zinc group and 24% in control group (P = .004). The highest incidence of POST occurred at the second hour after surgery, with the rate of 10% in the zinc group and 34% in the control group (P = .0495). The incidence of POST at 24 hours was 13% in zinc group and 24% in control group (not significant). The severity of POST was significantly lower in the zinc group for mild (P = .003) and moderate (P = .004) POST.
The administration of a single dose of 40-mg zinc lozenge 30 minutes preoperatively is effective to reduce both incidence of POST in the first 4 hours and severity of mild and moderate POST in the immediate postoperative period.
术后咽痛（POST）是气管插管后常见的情况，口服锌可预防化疗相关的口腔黏膜炎。本研究旨在评估含锌含片给药对POST的影响。
79例接受低或中度风险手术并进行气管插管的患者被随机分为2组：对照组接受安慰剂，锌组在术前30分钟接受40毫克含锌含片。在术后0、2、4和24小时评估患者POST的发生率和严重程度（4分制，0 - 3分）。主要结局是术后4小时POST的发生率。次要结局是术后0、2和24小时POST的发生率以及POST的严重程度。
在4小时时，锌组POST的发生率显著低于对照组，分别为7%和29%（P = .046）。锌组术后0小时POST的发生率为0%，对照组为24%（P = .004）。POST的最高发生率出现在术后第2小时，锌组为10%，对照组为34%（P = .0495）。锌组术后24小时POST的发生率为13%，对照组为24%（无显著差异）。锌组轻度（P = .003）和中度（P = .004）POST的严重程度显著较低。
术前30分钟单次给予40毫克含锌含片可有效降低术后前4小时POST的发生率以及术后即刻轻度和中度POST的严重程度。
