Shabbir Talha, Kal Sarala, Gupta Saloni, Hunsucker Rachel, Siddiqui Danish
Research, California University of Science and Medicine, Colton, USA.
Internal Medicine, Arrowhead Regional Medical Center, Colton, USA.
Cureus. 2023 Feb 17;15(2):e35106. doi: 10.7759/cureus.35106. eCollection 2023 Feb.
Takotsubo cardiomyopathy (TC) is a transient condition characterized by left ventricular wall motion abnormalities, ventricular systolic dysfunction, and apical ballooning. When initially presented, the pathology is often erroneously attributed to acute coronary syndrome (ACS) or acute-onset heart failure due to similar symptoms and electrocardiogram (ECG) findings. However, upon further review of imaging, coronary arteries are often void of disease. The highest prevalence of Takotsubo cardiomyopathy is noted in elderly, postmenopausal women who recently experienced an emotionally or physically triggering event. Although the true underlying pathophysiology of Takotsubo cardiomyopathy remains poorly elucidated, a few leading concepts suggest that stress-induced sympathetic responses may lead to catecholamine-induced cardiotoxicity. Other ideologies implicate poor coronary perfusion, neurogenic myocardial stunning, and coronary artery vasospasms. As features of TC are transient, it has an excellent prognosis, and patients see improvement in ventricular function and symptoms within weeks after the initiation of therapy. In this paper, we discuss a case of TC noted incidentally on imaging in a middle-aged female presenting with encephalopathy after a motor vehicle accident.
应激性心肌病(TC)是一种短暂性疾病,其特征为左心室壁运动异常、心室收缩功能障碍和心尖部气球样变。最初出现时,由于症状和心电图(ECG)表现相似,其病理情况常被错误地归因于急性冠状动脉综合征(ACS)或急性心力衰竭。然而,进一步检查影像学资料时,冠状动脉通常无病变。应激性心肌病在近期经历过情绪或身体触发事件的老年绝经后女性中患病率最高。尽管应激性心肌病真正的潜在病理生理学仍未完全阐明,但一些主要观点认为,应激诱导的交感反应可能导致儿茶酚胺诱导的心脏毒性。其他理论则涉及冠状动脉灌注不良、神经源性心肌顿抑和冠状动脉痉挛。由于应激性心肌病的特征是短暂性的,其预后良好,患者在开始治疗后的几周内心室功能和症状会有所改善。在本文中,我们讨论了一例在机动车事故后出现脑病的中年女性患者,其应激性心肌病在影像学检查中偶然被发现。