Merlo G, Ambroggio G P, Mosca A, Oberto E
Institute of Surgical Pathology, University of Turin, Italy.
J Hand Surg Am. 1987 Nov;12(6):1017-9. doi: 10.1016/s0363-5023(87)80101-6.
Increased amounts of plasminogen activator enzymes were found in the large Dupuytren's nodules in the so-called active phase of the disease. A prospective study in 15 patients who had operations investigated possible relationships between fibrinolytic capacity of the palmar nodules (assessed by the fibrin plate method) and the recurrence of contracture. There were substantial analogies and suggestive connections with the results of previous electron microscopic studies. Combined with the presence of myofibroblasts, the high increase of plasminogen activator enzymes in the fascial nodules may be regarded as a predictive marker for possible recurrence after surgical treatment of Dupuytren's contracture.
在疾病的所谓活跃期，在较大的杜普伊特伦结节中发现纤溶酶原激活酶的含量增加。对15例接受手术的患者进行的一项前瞻性研究，调查了掌部结节的纤溶能力（通过纤维蛋白平板法评估）与挛缩复发之间的可能关系。这些结果与先前电子显微镜研究的结果有大量相似之处和暗示性联系。结合肌成纤维细胞的存在，筋膜结节中纤溶酶原激活酶的高度增加可被视为杜普伊特伦挛缩手术治疗后可能复发的预测标志物。
