Higashiyama Yuichi, Kuroki Miho, Kudo Yosuke, Hamada Tomoya, Morihara Keisuke, Saito Asami, Miyaji Yosuke, Kimura Katsuo, Joki Hideto, Kishida Hitaru, Doi Hiroshi, Ueda Naohisa, Takeuchi Hideyuki, Johkura Ken, Tanaka Fumiaki
Department of Neurology and Stroke Medicine, Graduate School of Medicine, Yokohama City University, Yokohama 236-0004, Japan.
Department of Neurology, Yokohama Brain and Spine Center, Yokohama 235-0012, Japan.
Brain Commun. 2023 Mar 6;5(2):fcad053. doi: 10.1093/braincomms/fcad053. eCollection 2023.
This study aimed to test our hypothesis that the cerebellum plays an important role in the generation of the optical-geometric illusion known as the Poggendorff illusion, the mechanism of which has been explained by accumulated experience with natural scene geometry. A total of 79 participants, comprising 28 patients with isolated cerebellar stroke, 27 patients with isolated cerebral stroke and 24 healthy controls, performed Poggendorff illusion tasks and 2 different control tasks. We also investigated core brain regions underpinning changes in the experience of the illusion effect using multivariate lesion-symptom mapping. Our results indicate that patients with isolated cerebellar stroke were significantly less likely to experience the Poggendorff illusion effect than patients with isolated cerebral stroke or healthy controls (74.6, 90.5 and 89.8%, respectively; (2,76) = 6.675, = 0.002). However, there were no inter-group differences in the control tasks. Lesion-symptom mapping analysis revealed that the brain lesions associated with the reduced frequency of the Poggendorff illusion effect were mainly centred on the right posteromedial cerebellar region, including the right lobules VI, VII, VIII, IX and Crus II. Our findings demonstrated, for the first time, that patients with cerebellar damage were significantly less likely to experience the Poggendorff illusion effect and that right posteromedial cerebellar lesions played an important role in this effect. These results provide new insight into alterations of a geometric illusion effect in patients with cerebellar disorders and pave the way for future clinical use of the illusion task to detect cerebellar abnormalities.
本研究旨在验证我们的假设，即小脑在一种被称为波根多夫错觉的光学几何错觉的产生中起重要作用，其机制已通过对自然场景几何的积累经验得到解释。共有79名参与者，包括28例孤立性小脑卒患者、27例孤立性脑卒患者和24名健康对照者，进行了波根多夫错觉任务和2种不同的对照任务。我们还使用多变量损伤-症状映射研究了支撑错觉效应体验变化的核心脑区。我们的结果表明，孤立性小脑卒患者比孤立性脑卒患者或健康对照者体验到波根多夫错觉效应的可能性显著降低（分别为74.6%、90.5%和89.8%；(2,76)=6.675，P=0.002）。然而，在对照任务中，组间没有差异。损伤-症状映射分析显示，与波根多夫错觉效应频率降低相关的脑损伤主要集中在右后内侧小脑区域，包括右小叶VI、VII、VIII、IX和小脑脚II。我们的研究结果首次表明，小脑损伤患者体验到波根多夫错觉效应的可能性显著降低，并且右后内侧小脑损伤在这种效应中起重要作用。这些结果为小脑疾病患者几何错觉效应的改变提供了新的见解，并为未来使用错觉任务检测小脑异常的临床应用铺平了道路。
