Department of Otorhinolaryngology, The Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China.
Clin Respir J. 2023 Mar;17(3):139-147. doi: 10.1111/crj.13589. Epub 2023 Jan 31.
Obstructive sleep apnea (OSA) can lead to multisystem and multiorgan damage, which has attracted widespread attention from scholars. The pathogenesis of OSA is complex, and obesity plays an important role. Adipokine is secreted by adipose tissue, and its abnormal expression may be closely related to OSA. The relationship between omentin (a novel adipokine) and OSA is controversial. This study focuses on the important role of omentin in OSA and explores whether it can be regarded as a new target for the diagnosis and treatment of OSA.
PubMed, Embase, Web of Science, the Cochrane library, WANFANG, VIP, and Chinese National Knowledge Infrastructure were systematically searched for retrieving eligible studies until May 2022. Documents were screened according to strict inclusion and exclusion criteria, and data were extracted using Excel spreadsheets. The quality of the literature was assessed using the Newcastle-Ottawa Scale. RevMan 5.3 and Stata 12.0 software were used in this meta-analysis for data synthesis.
A total of eight eligible studies with 23 databases involving 914 participants were included in this meta-analysis. Combined data indicated that omentin levels in OSA patients were lower than that in controls (standardized mean difference = -1.54, 95% confidence interval = -2.07 to -1.00, p < 0.001). According to the subgroup analysis results of different races, sample source, gender, and the severity of the disease, compared with that in the control group, the level of omentin in OSA patients was significantly lower. When conducting sensitivity analysis, the results of the study were less stable. Meta-analysis indicated that there was no publication bias in this study. The omentin levels were significantly lower in OSA patients. The findings suggest that omentin may be a potential marker for the diagnosis and treatment of OSA. However, the heterogeneity of this study is high, and more high-quality large-sample studies will be needed in the future.
阻塞性睡眠呼吸暂停（OSA）可导致多系统、多器官损伤，引起学者广泛关注。OSA 的发病机制复杂，肥胖发挥着重要作用。脂肪细胞因子由脂肪组织分泌，其异常表达可能与 OSA 密切相关。内脂素（一种新型脂肪细胞因子）与 OSA 的关系存在争议。本研究聚焦于内脂素在 OSA 中的重要作用，探讨其是否可作为 OSA 诊断和治疗的新靶点。
系统检索 PubMed、Embase、Web of Science、Cochrane 图书馆、万方、维普、中国知网，检索时限均从建库至 2022 年 5 月，筛选纳入符合标准的研究，采用 Excel 表格提取数据，采用 Newcastle-Ottawa 量表评价文献质量，Meta 分析采用 RevMan 5.3 和 Stata 12.0 软件进行数据合成。
共纳入 8 项研究，23 个数据库，914 例患者，Meta 分析结果显示，OSA 患者内脂素水平低于对照组[标准化均数差（SMD）=-1.54，95%置信区间（CI）=-2.07 至-1.00，P<0.001]。根据不同种族、样本来源、性别、疾病严重程度的亚组分析结果，OSA 患者内脂素水平均明显低于对照组。行敏感性分析时，研究结果稳定性欠佳。Meta 分析结果表明，本研究不存在发表偏倚。OSA 患者内脂素水平显著降低。提示内脂素可能是 OSA 诊断和治疗的潜在标志物。但本研究异质性较高，未来需要更多高质量大样本研究加以验证。
