从 中分离得到的两个新吲哚生物碱及其细胞毒性活性评价。
Two new indole alkaloids from and their evaluation for cytotoxic activities.
机构信息
School of Pharmacy, Shenyang Pharmaceutical University, Shenyang, P. R. China.
School of Traditional Chinese Medicine, Shenyang Pharmaceutical University, Shenyang, P. R. China.
出版信息
Nat Prod Res. 2024 Feb-Mar;38(4):607-613. doi: 10.1080/14786419.2023.2189707. Epub 2023 Mar 20.
Two new indole alkaloids, naucleamide H () and (±)-19--butylangustoline (), along with seven known alkaloids, 3,14-dihydroangustine (), (-)-naucleofficine D (), (+)-naucleofficine D (), nauclefine (), angustidine (),19--ethylangustoline () and angustine () were isolated from the water extract of . The structures of these compounds were established by spectroscopic analysis. Among them, the cytotoxicity of , , and were evaluated against six human cancer cell lines (HepG-2, SKOV3, HeLa, SGC 7901, MCF-7 and KB) for the first time with 5-fluorouracil as a positive control drug. The new compound had a strong inhibitory effect on the proliferation of HepG-2 with an IC value of 19.59 μg/mL. The new compound had a strong inhibitory effect on HepG-2, SKOV3, HeLa, MCF-7 and KB, IC value was 5.530, 23.11, 31.30, 32.42 and 37.26 μg/mL, respectively.
从. 的水提取物中分离得到了两个新的吲哚生物碱，Naucleamide H () 和 (±)-19--Butylangustoline ()，以及 7 个已知生物碱，3,14-二氢 Angustine (), (-)-Naucleofficine D (), (+)-Naucleofficine D (), Nauclefine (), Angustidine (),19--Ethylangustoline () 和 Angustine ()。这些化合物的结构通过光谱分析确定。其中，首次对化合物 、 、 和 进行了六种人癌细胞系（HepG-2、SKOV3、HeLa、SGC 7901、MCF-7 和 KB）的体外细胞毒性评价，5-氟尿嘧啶为阳性对照药物。新化合物 对 HepG-2 的增殖具有很强的抑制作用，IC 值为 19.59 μg/mL。新化合物 对 HepG-2、SKOV3、HeLa、MCF-7 和 KB 的抑制作用较强，IC 值分别为 5.530、23.11、31.30、32.42 和 37.26 μg/mL。
Zotero 插件