Department of Chemistry, Faculty of Science, University of Malaya, 50603 Kuala Lumpur, Malaysia.
Molecules. 2012 Apr 2;17(4):4028-36. doi: 10.3390/molecules17044028.
A new indole alkaloid, naucline (1) together with four known alkaloids, angustine (2), angustidine (3), nauclefine (4) and naucletine (5), were isolated from the bark of Nauclea officinalis. The structures of all isolated compounds were elucidated with various spectroscopic methods such as 1D- and 2D- NMR, IR, UV and LCMS-IT-TOF. In addition to that of alkaloid 1, the complete 13C-NMR data of naucletine (5) were also reported. Naucline (1) showed a moderate vasorelaxant activity (90% relaxation at 1 × 10(-5) M) whereas, angustine (2), nauclefine (4), and naucletine (5) showed potent vasorelaxant activity (more than 90% relaxation at 1 × 10(-5) M) on an isolated rat aorta.
从乌檀属植物的树皮中分离得到一个新的吲哚生物碱 Naucline（1）以及另外四个已知生物碱：angustine（2）、angustidine（3）、nauclefine（4）和 naucletine（5）。通过各种光谱方法（如 1D 和 2D-NMR、IR、UV 和 LCMS-IT-TOF）确定了所有分离化合物的结构。除了生物碱 1 的结构外，还报道了 naucletine（5）的完整 13C-NMR 数据。Naucline（1）表现出中等的血管舒张活性（在 1×10(-5) M 时达到 90%的舒张率），而 angustine（2）、nauclefine（4）和 naucletine（5）在离体大鼠主动脉中表现出很强的血管舒张活性（在 1×10(-5) M 时超过 90%的舒张率）。
