从 中分离得到的齐墩果-9(11),12-二烯-3-醇的 NMR 光谱数据的重新归属及其在细胞迁移和促血管生成活性方面的伤口愈合潜力。
Reassignment of NMR spectroscopic data of oleana-9(11),12-diene-3-ol isolated from and its wound healing potential in terms of cell migration and proangiogenic activity.
机构信息
Department of Chemistry, The Open University of Sri Lanka, Nugegoda, Sri Lanka.
Department of Zoology, The Open University of Sri Lanka, Nugegoda, Sri Lanka.
出版信息
Nat Prod Res. 2024 Aug;38(15):2577-2584. doi: 10.1080/14786419.2023.2190112. Epub 2023 Mar 20.
(Asteraceae), a plant endemic to Sri Lanka, is used for the treatment of wounds. The scratch wound assay (SWA) guided fractionation of hexanes extract of led to the isolation of oleana-9(11),12-diene-3-ol () which showed enhanced cell migration in SWA and significant proangiogenic response in chorioallantoic membrane (CAM) assay. Since the reported H NMR assignments of were incomplete, and some C NMR assignments were inconsistent with our observations, reassignment of NMR spectroscopic data of was carried out. Herein we report unambiguous assignment of NMR data of based on 1D and 2D NMR spectra. This is the first report of in .
(菊科)，斯里兰卡特有的一种植物，用于治疗伤口。划痕伤口测定 (SWA) 指导的正己烷提取物的分段分离导致了 oleana-9(11),12-diene-3-ol () 的分离，它在 SWA 中显示出增强的细胞迁移，并且在绒毛尿囊膜 (CAM) 测定中显示出显著的促血管生成反应。由于报道的 的 H NMR 分配不完整，并且一些 C NMR 分配与我们的观察结果不一致，因此对 的 NMR 波谱数据进行了重新分配。在此，我们根据 1D 和 2D NMR 谱报告了 的 NMR 数据的明确分配。这是 在 中的首次报道。
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