Department of Dermatology, Kaohsiung Veterans General Hospital, Kaohsiung, Taiwan.
Department of Pathology and Laboratory Medicine, Kaohsiung Veterans General Hospital, Kaohsiung, Taiwan.
Am J Dermatopathol. 2023 Jun 1;45(6):391-396. doi: 10.1097/DAD.0000000000002403. Epub 2023 Mar 20.
Lymphomatoid papulosis (LyP) with DUSP22-IRF4 rearrangement on chromosome 6p25.3 is a newly identified subtype of LyP. It is characterized by an older age of onset, localized skin lesions, with good prognosis, and it resembles a hybrid of LyP types B and C in histopathology. A limited number of cases have been reported so far. In this article, we reported a case of a 72-year-old man with recurrent episodes of widespread multiple discrete papular or vesicular eruptions on a region of the head, trunk, and 4 extremities for about 3 years. Histopathological examination of a vesicle revealed a subepidermal blister with abundant atypical lymphocytes in the vesicular space, band-like infiltrates in the papillary dermis, along with epidermotropism and pilosebaceous structure involvement. Fluorescence in situ hybridization analysis further demonstrated DUSP22-IRF4 rearrangement on chromosome 6p25.3. A diagnosis of vesicular LyP with this rare subtype was made according to the clinical and pathological findings.
伴有 6p25.3 染色体 DUSP22-IRF4 重排的蕈样肉芽肿病（LyP）是 LyP 的一种新的亚型。其特征为发病年龄较大、局限于皮肤的病变、预后良好，且在组织病理学上类似于 LyP 类型 B 和 C 的混合体。迄今为止，已报道了少数病例。本文报道了 1 例 72 岁男性，约 3 年来反复出现头部、躯干和四肢广泛多发离散性丘疹或水疱样皮损。水疱的组织病理学检查显示表皮下水疱，水疱腔内有大量非典型淋巴细胞，乳头真皮呈带状浸润，伴有表皮亲润和毛囊皮脂腺结构受累。荧光原位杂交分析进一步显示 6p25.3 染色体 DUSP22-IRF4 重排。根据临床和病理发现，诊断为伴有这种罕见亚型的水疱性 LyP。
