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一名曾被诊断为原发性皮肤间变性大细胞淋巴瘤的患者出现伴有DUSP22重排的淋巴瘤样丘疹病。

Lymphomatoid Papulosis With DUSP22 Rearrangement in a Patient With a Historical Diagnosis of Primary Cutaneous Anaplastic Large Cell Lymphoma.

作者信息

Monika Fnu, Li Shuai, Ambler Emily, Cantu David, Siref Andrew

机构信息

Department of Pathology, Creighton University School of Medicine, Omaha, USA.

Department of Pathology - Hematopathology, Creighton University School of Medicine, Omaha, USA.

出版信息

Cureus. 2024 Aug 2;16(8):e66022. doi: 10.7759/cureus.66022. eCollection 2024 Aug.

DOI:10.7759/cureus.66022
PMID:39221352
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11366282/
Abstract

Lymphomatoid papulosis (LyP) with  rearrangement is an uncommon subtype of lymphomatoid papulosis featured histologically by two distinct patterns of epidermotropic cells, weakly CD30+ small- to medium-sized T-cells and a dermal infiltrate of strongly CD30+ medium- to large-sized T-cells.  rearrangement is detected more frequently in anaplastic large cell lymphoma (ALCL) than in LyP. Primary cutaneous anaplastic large cell lymphoma (pcALCL) cases can also show a similar biphasic CD30 staining pattern. LyP with  rearrangement has a more indolent clinical course than pcALCL and is more likely to regress without treatment. Herein, we report a unique case of LyP with  rearrangement diagnosed in an 81-year-old female with a historical diagnosis of pcALCL, made 20 years prior.

摘要

伴有[某种重排]的淋巴瘤样丘疹病（LyP）是淋巴瘤样丘疹病的一种罕见亚型，其组织学特征为两种不同模式的亲表皮细胞，即弱CD30 +的小至中等大小T细胞和强CD30 +的中至大大小T细胞的真皮浸润。[某种重排]在间变性大细胞淋巴瘤（ALCL）中比在LyP中更频繁地被检测到。原发性皮肤间变性大细胞淋巴瘤（pcALCL）病例也可表现出类似的双相CD30染色模式。伴有[某种重排]的LyP临床病程比pcALCL更惰性，且更有可能未经治疗而消退。在此，我们报告一例伴有[某种重排]的LyP的独特病例，该病例发生在一名81岁女性身上，她在20年前曾被诊断为pcALCL。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/57bb/11366282/8f5a0fb44057/cureus-0016-00000066022-i03.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/57bb/11366282/9a0af4866676/cureus-0016-00000066022-i01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/57bb/11366282/25b0f7f45d33/cureus-0016-00000066022-i02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/57bb/11366282/8f5a0fb44057/cureus-0016-00000066022-i03.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/57bb/11366282/9a0af4866676/cureus-0016-00000066022-i01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/57bb/11366282/25b0f7f45d33/cureus-0016-00000066022-i02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/57bb/11366282/8f5a0fb44057/cureus-0016-00000066022-i03.jpg

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本文引用的文献

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Primary cutaneous anaplastic large cell lymphoma with DUSP22-rearrangement presenting as a mimicker of mycosis fungoides: a case report and review of the literature.伴有DUSP22重排的原发性皮肤间变性大细胞淋巴瘤表现为蕈样肉芽肿的模仿者：一例报告并文献复习
Leuk Lymphoma. 2024 Feb;65(2):265-269. doi: 10.1080/10428194.2023.2276678. Epub 2024 Jan 24.
2
DUSP22-IRF4 Rearranged CD30-Positive Primary Cutaneous Lymphoproliferative Disorder With Gamma/Delta Phenotype.DUSP22-IRF4 重排的 CD30 阳性原发性皮肤淋巴增生性疾病，伴γ/δ表型。
Am J Dermatopathol. 2023 Dec 1;45(12):831-834. doi: 10.1097/DAD.0000000000002573.
3
Primary cutaneous T-cell lymphoma: a review of the most common entities with focus on recent updates.
原发性皮肤T细胞淋巴瘤：对最常见实体的综述，重点关注近期进展。
Hum Pathol. 2023 Aug;138:76-102. doi: 10.1016/j.humpath.2023.06.001. Epub 2023 Jun 10.
4
Lymphomatoid papulosis with DUSP22-IRF4 rearrangement: A case report and literature review.伴 DUSP22-IRF4 重排的蕈样肉芽肿：一例报告并文献复习。
J Cutan Pathol. 2023 Aug;50(8):711-716. doi: 10.1111/cup.14426. Epub 2023 Mar 21.
5
Vesicular Lymphomatoid Papulosis With DUSP22-IRF4 Rearrangement on Chromosome 6p25.3: A Case Report.伴有 DUSP22-IRF4 基因重排的滤泡性淋巴瘤样丘疹病：1 例报告。
Am J Dermatopathol. 2023 Jun 1;45(6):391-396. doi: 10.1097/DAD.0000000000002403. Epub 2023 Mar 20.
6
Recent advances in cutaneous lymphoma-implications for current and future classifications.皮肤淋巴瘤的最新进展——对当前和未来分类的影响。
Virchows Arch. 2023 Jan;482(1):281-298. doi: 10.1007/s00428-022-03421-5. Epub 2022 Oct 24.
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The 5th edition of the World Health Organization Classification of Haematolymphoid Tumours: Lymphoid Neoplasms.《世界卫生组织造血与淋巴组织肿瘤分类》第五版：淋巴肿瘤。
Leukemia. 2022 Jul;36(7):1720-1748. doi: 10.1038/s41375-022-01620-2. Epub 2022 Jun 22.
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Patch/plaque mycosis-fungoides-like presentations of DUSP22-translocated T-cell lymphomas.DUSP22 易位 T 细胞淋巴瘤呈斑块样/苔藓样蕈样肉芽肿表现。
J Cutan Pathol. 2022 Mar;49(3):299-305. doi: 10.1111/cup.14156. Epub 2021 Nov 7.
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DUSP22 rearrangement in primary cutaneous T cell lymphoma with features intermediate between mycosis fungoides, anaplastic large-cell lymphoma and lymphomatoid papulosis.原发性皮肤T细胞淋巴瘤中的DUSP22重排，其特征介于蕈样肉芽肿、间变性大细胞淋巴瘤和淋巴瘤样丘疹病之间。
Histopathology. 2022 Jan;80(2):446-449. doi: 10.1111/his.14448. Epub 2021 Sep 5.
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-rearranged anaplastic lymphomas are characterized by specific morphological features and a lack of cytotoxic and JAK/STAT surrogate markers.重排的间变性淋巴瘤具有特定的形态学特征，且缺乏细胞毒性和JAK/STAT替代标志物。
Haematologica. 2019 Apr;104(4):e158-e162. doi: 10.3324/haematol.2018.205880. Epub 2018 Oct 25.