Department of Biomedical Engineering, Washington University.
Department of Electrical & Systems Engineering, Washington University.
J Vis Exp. 2023 Mar 3(193). doi: 10.3791/64864.
Ovarian cancer remains the deadliest of all the gynecological malignancies due to the lack of reliable screening tools for early detection and diagnosis. Photoacoustic imaging or tomography (PAT) is an emerging imaging modality that can provide the total hemoglobin concentration (relative scale, rHbT) and blood oxygen saturation (%sO2) of ovarian/adnexal lesions, which are important parameters for cancer diagnosis. Combined with coregistered ultrasound (US), PAT has demonstrated great potential for detecting ovarian cancers and for accurately diagnosing ovarian lesions for effective risk assessment and the reduction of unnecessary surgeries of benign lesions. However, PAT imaging protocols in clinical applications, to our knowledge, largely vary among different studies. Here, we report a transvaginal ovarian cancer imaging protocol that can be beneficial to other clinical studies, especially those using commercial ultrasound arrays for the detection of photoacoustic signals and standard delay-and-sum beamforming algorithms for imaging.
由于缺乏可靠的筛查工具用于早期检测和诊断，卵巢癌仍然是所有妇科恶性肿瘤中最致命的一种。光声成像是一种新兴的成像方式，可以提供卵巢/附件病变的总血红蛋白浓度（相对标度，rHbT）和血氧饱和度（%sO2），这是癌症诊断的重要参数。与配准的超声（US）相结合，光声成像已显示出在检测卵巢癌和准确诊断卵巢病变方面具有很大的潜力，可有效评估风险，并减少对良性病变的不必要手术。然而，据我们所知，在临床应用中，光声成像协议在不同的研究中差异很大。在这里，我们报告了一种经阴道卵巢癌成像协议，这对其他临床研究可能有益，特别是那些使用商业超声阵列来检测光声信号和标准的延迟和求和波束形成算法来进行成像的研究。
