von Knorring Terese, Mogensen Mette
Department of Dermatology, Bispebjerg University Hospital, University of Copenhagen, Bispebjerg Bakke 23, Copenhagen, 2400, NV, Denmark.
Department of Dermatology, Bispebjerg University Hospital, University of Copenhagen, Bispebjerg Bakke 23, Copenhagen, 2400, NV, Denmark.
Photodiagnosis Photodyn Ther. 2021 Mar;33:102095. doi: 10.1016/j.pdpdt.2020.102095. Epub 2020 Nov 11.
Photoacoustic tomography (PAT) is an emerging noninvasive imaging technique combining high sensitivity optical absorption contrast, such as melanin, with high-resolution ultrasound for deep tissue imaging. The ability of PAT to provide real-time images of skin structures at depth has been studied for diagnosis of primary and metastatic malignant melanoma (MM).
To provide an overview of the rapidly expanding clinical use of PAT for determination of melanoma thickness and architecture, visualization of metastases in lymph nodes and detection of circulating melanoma cells.
Medline, PubMed, EMBASE, Web of Science, Google Scholar, and Cochrane Library were searched for papers using PAT to assess cutaneous malignant melanoma and melanoma metastases in humans or human specimens.
The research resulted in 14 articles which met the search criteria.
Results from current studies suggest that PAT is a promising tool for assessing both primary and metastatic malignant melanoma in the clinic. The potential of PAT to noninvasively visualize tumour boundaries, as well as assist in the evaluation of metastatic status, could facilitate more effective treatment, resulting in better clearance and reducing the need for additional biopsies. However, larger and methodologically sound studies are warranted.
光声断层扫描（PAT）是一种新兴的非侵入性成像技术，它将高灵敏度的光学吸收对比（如黑色素）与高分辨率超声相结合，用于深部组织成像。PAT在深度提供皮肤结构实时图像的能力已被研究用于原发性和转移性恶性黑色素瘤（MM）的诊断。
概述PAT在确定黑色素瘤厚度和结构、可视化淋巴结转移以及检测循环黑色素瘤细胞方面迅速扩展的临床应用。
检索Medline、PubMed、EMBASE、科学网、谷歌学术和考克兰图书馆，查找使用PAT评估人类或人类标本中皮肤恶性黑色素瘤和黑色素瘤转移的论文。
该研究产生了14篇符合检索标准的文章。
目前的研究结果表明，PAT是临床上评估原发性和转移性恶性黑色素瘤的一种有前景的工具。PAT非侵入性可视化肿瘤边界以及协助评估转移状态的潜力，可促进更有效的治疗，实现更好的清除效果并减少额外活检的需求。然而，需要开展更大规模且方法合理的研究。
