Hypertension Research Center, Cardiovascular Research Institute, Isfahan University of Medical Sciences, Isfahan, Iran.
Biostatistics and Epidemiology Department, School of Health, Isfahan University of Medical Sciences, Isfahan, Iran.
Crit Rev Food Sci Nutr. 2023;63(14):2247-2259. doi: 10.1080/10408398.2021.1973364. Epub 2023 Mar 20.
This systematic review and meta-analysis aimed at summarizing earlier findings on the association of n-6 PUFAs levels in diets or blood with blood pressure.
PubMed/Medline, Scopus, and Web of Science were searched for observational studies. Publications with data on the risk of hypertension, or the correlation between n-6 PUFAs or mean values of serum n-6 PUFAs levels in normotensive and hypertensive were included.
Twenty-two studies (16 cross-sectional studies, 5 cohorts and one case-control) were eligible. Combining 14 extracted effect sizes showed that higher circulatory/dietary n-6 PUFAs tended to be associated with 10% lower risk of HTN (95% CI: 0.81, 1.00), whereas combining 23 effect sizes illustrated no difference in circulatory/dietary n-6 PUFAs mean levels between normotensive and hypertensive subjects. According to subgroup analysis based on fatty acid types, total n-6 PUFAs (OR = 0.82, 95% CI: 0.70, 0.97) and linoleic acid (OR = 0.56, 95% CI: 0.39, 0.82) were inversely related to the risk of HTN. Circulatory/dietary n-6 PUFAs were correlated neither with systolic nor with diastolic blood pressure.
Higher circulatory/dietary n-6 PUFAs tend to be associated with lower odds of HTN. Particularly, total n-6 PUFAs and linoleic acid were associated with lower risk of HTN.
本系统评价和荟萃分析旨在总结饮食或血液中 n-6 多不饱和脂肪酸（PUFAs）水平与血压之间关联的早期研究结果。
检索了 PubMed/Medline、Scopus 和 Web of Science 中的观察性研究。纳入了有高血压风险数据的出版物，或纳入了 n-6 PUFAs 或正常血压和高血压患者血清 n-6 PUFAs 平均水平之间相关性的数据的出版物。
有 22 项研究（16 项横断面研究、5 项队列研究和 1 项病例对照研究）符合条件。合并 14 项提取的效应量表明，循环/饮食中 n-6 PUFAs 水平较高与 HTN 风险降低 10%相关（95%CI：0.81，1.00），而合并 23 项效应量表明，正常血压和高血压患者之间循环/饮食中 n-6 PUFAs 平均水平无差异。根据基于脂肪酸类型的亚组分析，总 n-6 PUFAs（OR=0.82，95%CI：0.70，0.97）和亚油酸（OR=0.56，95%CI：0.39，0.82）与 HTN 风险呈负相关。循环/饮食 n-6 PUFAs 与收缩压或舒张压均无相关性。
循环/饮食中 n-6 PUFAs 水平较高与 HTN 发生的几率较低相关。特别是总 n-6 PUFAs 和亚油酸与 HTN 风险降低相关。
