Tianjin Key Laboratory of Metabolic Diseases, Collaborative Innovation Center of Tianjin for Medical Epigenetics, Department of Physiology and Pathophysiology, Tianjin Medical University, Tianjin, China.
Antioxid Redox Signal. 2021 Apr 1;34(10):800-810. doi: 10.1089/ars.2020.8108. Epub 2020 Jun 12.
Hypertension is characterized as the imbalance of vasoconstriction and vasodilatation. Hypertension is influenced by genetic variation and environmental risk factors, such as unhealthy diet. Clinical trial results suggest that increasing intake of foods rich in n-3 polyunsaturated fatty acids (PUFAs) is beneficial for hypertension. We summarized recent clinical trials regarding supplementation with n-3 PUFAs to reduce blood pressure (BP) in untreated hypertensive and normotensive subjects and systematically discussed the antihypertension mechanisms of n-3 PUFAs/n-3 oxylipins, including reducing oxidative stress, altering functions of membrane-related proteins, and competing with n-6 PUFAs/n-6 oxylipins in regulating vasodilator release. Previous studies considered n-3 PUFAs as single molecules with beneficial roles in hypertension. Recently, researchers have paid more attention to the metabolism of n-3 PUFAs and explored molecular mechanisms of n-3 PUFAs and oxylipins derived from n-3 PUFAs in hypertension interventions. Based on the metabolism of n-3 PUFAs/n-3 oxylipins and mechanisms in BP control, we suggested that supplementation of n-3 PUFAs combined with agents targeting PUFA metabolism or the related signal pathways may amplify their effects to treat hypertension and other cardiovascular diseases. 34, 800-810.
高血压的特征是血管收缩和血管舒张的失衡。高血压受遗传变异和环境风险因素的影响，如不健康的饮食。临床试验结果表明，增加富含 n-3 多不饱和脂肪酸（PUFA）的食物摄入对高血压有益。我们总结了最近关于补充 n-3 PUFAs 以降低未经治疗的高血压和血压正常受试者血压的临床试验，并系统地讨论了 n-3 PUFAs/n-3 氧化脂类物质的降压机制，包括降低氧化应激、改变膜相关蛋白的功能以及与 n-6 PUFAs/n-6 氧化脂类物质竞争以调节血管舒张剂的释放。以前的研究认为 n-3 PUFAs 是单一分子，对高血压有有益作用。最近，研究人员更加关注 n-3 PUFAs 的代谢，并探索了 n-3 PUFAs 和 n-3 PUFAs 衍生的氧化脂类物质在高血压干预中的分子机制。基于 n-3 PUFAs/n-3 氧化脂类物质的代谢和血压控制机制，我们建议补充 n-3 PUFAs 与靶向 PUFA 代谢或相关信号通路的药物联合使用，可能会增强其治疗高血压和其他心血管疾病的效果。34, 800-810.
