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疼痛障碍和精神疾病与阻塞性睡眠呼吸暂停的手术治疗的相关性。

Association of Pain Disorder and Psychiatric Disease With Surgical Management of Obstructive Sleep Apnea.

机构信息

Department of Otolaryngology, Head and Neck Surgery, Kaiser Permanente, East Bay, Oakland, California, USA.

Division of Research, Kaiser Permanente Northern California, Oakland, California, USA.

出版信息

Otolaryngol Head Neck Surg. 2023 Jun;168(6):1557-1566. doi: 10.1002/ohn.223. Epub 2023 Feb 5.

Abstract

OBJECTIVE

Patients undergoing surgical management for obstructive sleep apnea (OSA) are likely medically distinct from their counterparts not treated surgically. This study examined the associations between psychiatric and pain comorbidities and the likelihood of undergoing sleep surgery.

STUDY DESIGN

A retrospective cohort study of adults with OSA.

SETTING

Large integrated healthcare system.

METHODS

The primary outcome was nonnasal, nonbariatric sleep surgery. The associations of baseline demographic and comorbid conditions with surgery to treat underlying OSA were examined using bivariable and multivariable analyses.

RESULTS

Among 172,854 adults with OSA, 2456 received sleep surgery. Comorbid pain disorder and/or pain medication treatment was associated with 41% higher odds of surgery (95% confidence interval: 1.29-1.54). In bivariable analyses, those with a history of headache (p = .004), particularly migraine (p = .003), disorders of adult personality or behavior (p = .025), or behavioral/emotional disorder (p < .001) were more likely to undergo surgery. Younger adults were also more likely to undergo surgery (mean age at diagnosis 39.8 ± 12.6 vs 54.7 ± 14 years), as were men, Asian/Pacific Islander or Hispanic adults, those with lower body mass index (32 ± 7 vs 34.3 ± 8.1 kg/m ), or those with Charlson Comorbidity Index of zero (p < .001).

CONCLUSION

Our study suggests a history of pain disorder (including receipt of pain medication), migraine, or certain behavioral and personality disorders are associated with an increased likelihood of undergoing sleep surgery. The findings may better characterize comorbid predictors of sleep surgery and potentially help clinicians tailor expectations, postoperative pain management, and overall sleep outcomes.

摘要

目的

接受手术治疗阻塞性睡眠呼吸暂停(OSA)的患者可能与未经手术治疗的患者在医学上存在明显差异。本研究探讨了精神和疼痛合并症与接受睡眠手术的可能性之间的关联。

研究设计

一项对 OSA 成年患者的回顾性队列研究。

研究地点

大型综合医疗系统。

方法

主要结局是非鼻、非减肥睡眠手术。使用双变量和多变量分析检查基线人口统计学和合并症与治疗潜在 OSA 的手术之间的关联。

结果

在 172854 名患有 OSA 的成年人中,有 2456 人接受了睡眠手术。合并疼痛障碍和/或疼痛药物治疗与手术的可能性增加 41%(95%置信区间:1.29-1.54)相关。在双变量分析中,有头痛史(p = .004),特别是偏头痛(p = .003)、成人人格或行为障碍(p = .025)或行为/情绪障碍(p < .001)的患者更有可能接受手术。年轻患者也更有可能接受手术(诊断时的平均年龄为 39.8 ± 12.6 岁,而 54.7 ± 14 岁),男性、亚洲/太平洋岛民或西班牙裔成年人、体重指数较低(32 ± 7 岁,而 34.3 ± 8.1 岁/公斤),或 Charlson 合并症指数为零(p < .001)的患者也是如此。

结论

我们的研究表明,疼痛障碍史(包括接受疼痛药物治疗)、偏头痛或某些行为和人格障碍与接受睡眠手术的可能性增加相关。这些发现可能更好地描述睡眠手术的合并症预测因素,并有可能帮助临床医生调整预期、术后疼痛管理和整体睡眠结果。

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