Department of Medical and Clinical Psychology, CoRPS - Center of Research on Psychological Disorders and Somatic Diseases, Tilburg University, Tilburg, the Netherlands.
Department of Research, Netherlands Comprehensive Cancer Organisation (IKNL), Utrecht, the Netherlands.
Acta Oncol. 2023 Jul;62(7):676-688. doi: 10.1080/0284186X.2023.2187260. Epub 2023 Mar 20.
Around 30% of cancer survivors suffer from chemotherapy-induced peripheral neuropathy (CIPN) ≥6 months after completion of chemotherapy, which comes with limitations in daily functioning and worsened quality of life(QoL). Treatment options are scarce. Our aim was to develop an online self-help intervention based on Acceptance and Commitment Therapy (ACT) to reduce pain interference in cancer survivors experiencing painful chronic CIPN.
This article applied a patient-centered design process using the Center for eHealth Research (CeHRes) roadmap. User needs were examined using online semi-structured interviews with patients and experts ( = 23). Interviews were transcribed verbatim and analyzed using thematic analysis. Personas were created based on interviews. Intervention content was based on identified user needs and ACT. Content and design were finalized using low-fidelity prototype testing ( = 5), and high-fidelity prototype testing ( = 7).
Patients appreciated and agreed with the elements of ACT, had varying guidance needs, and wanted to have autonomy (e.g., moment and duration of use). Additionally, it was important to be aware that patients have had a life-threatening disease which directly relates to the symptoms they experience. Patients reported to prefer a user-friendly and accessible intervention. Similar points also emerged in the expert interviews. The final intervention, named , includes six sessions. Session content is based on psychoeducation and all ACT processes. Further interpretation of the intervention (such as quotes, guidance, and multimedia choices) is based on the interviews.
This development demonstrated how a patient-centered design process from a theoretical framework can be applied. Theory-driven content was used as the basis of the intervention. Findings show an online ACT intervention designed for cancer survivors with painful chronic CIPN.
约 30%的癌症幸存者在化疗结束后 6 个月以上仍患有化疗引起的周围神经病变（CIPN），这导致他们日常活动受限，生活质量（QoL）下降。治疗选择有限。我们的目的是开发一种基于接受与承诺疗法（ACT）的在线自助干预措施，以减轻患有慢性疼痛性 CIPN 的癌症幸存者的疼痛干扰。
本文采用以患者为中心的设计流程，使用电子健康研究中心（CeHRes）路线图。通过对患者和专家（ = 23）进行在线半结构化访谈来检查用户需求。访谈逐字记录并使用主题分析进行分析。根据访谈创建角色。干预内容基于确定的用户需求和 ACT。使用低保真原型测试（ = 5）和高保真原型测试（ = 7）最终确定内容和设计。
患者对 ACT 的元素表示赞赏和认同，他们的指导需求各不相同，并希望拥有自主权（例如，使用的时间和时长）。此外，了解患者患有危及生命的疾病，这与他们所经历的症状直接相关也很重要。患者报告称更喜欢用户友好且易于访问的干预措施。专家访谈中也出现了类似的观点。最终的干预措施命名为，包括六个模块。模块内容基于心理教育和所有 ACT 流程。干预的进一步解释（如引用、指导和多媒体选择）基于访谈。
本研究展示了如何从理论框架应用以患者为中心的设计流程。理论驱动的内容被用作干预的基础。研究结果显示，针对患有慢性疼痛性 CIPN 的癌症幸存者设计了一种在线 ACT 干预措施。
