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2020 年,1995 年至 2020 年期间美国国立卫生研究院资助的外科医生科学家的性别差异。

Gender Disparity in National Institutes of Health Funding Among Surgeon-Scientists From 1995 to 2020.

机构信息

Yale School of Medicine, New Haven, Connecticut.

Section of General Internal Medicine, Department of Medicine, Yale School of Medicine, New Haven, Connecticut.

出版信息

JAMA Netw Open. 2023 Mar 1;6(3):e233630. doi: 10.1001/jamanetworkopen.2023.3630.

Abstract

IMPORTANCE

Surgical diseases account for approximately 30% of the global burden of disease. Gender diversity in biomedical research is critical to generate innovative patient-centered research in surgery.

OBJECTIVE

To examine the distribution of biomedical research funding by the National Institutes of Health (NIH) among women and men surgeon-scientists during a 25-year period.

DESIGN, SETTING, AND PARTICIPANTS: This cross-sectional study used publicly available data from the NIH RePORTER (Research Portfolio Online Reporting Tools: Expenditures and Results) database for research project grants awarded to women and men surgeon-scientists who were principal investigators between 1995 and 2020. Data were retrieved between January 20 and March 20, 2022. The representation of women surgeon-scientists among academic surgeons was compared with the representation of men surgeon-scientists over time.

MAIN OUTCOMES AND MEASURES

Distribution of NIH funding to women and men surgeon-scientists was examined via 2 metrics: holding a large-dollar (ie, R01-equivalent) grant and being a super principal investigator (SPI) with $750 000 or more in total annual research funding. Statistical analysis was performed between April 1 and August 31, 2022.

RESULTS

Between 1995 and 2020, 2078 principal investigator surgeons received funding from the NIH. The proportion of women academic surgeons who were surgeon-scientists remained unchanged during this same period (1995, 14 of 792 [1.8%] vs 2020, 92 of 3834 [2.4%]; P = .10). Compared with their men counterparts, women surgeon-scientists obtained their first NIH grant earlier in their career (mean [SD] years after first faculty appointment, 8.8 [6.2] vs 10.8 [7.9] years; P < .001) and were as likely to obtain large-dollar grants (aRR, 0.99 [95% CI, 0.95-1.03]) during the period 2016 to 2020. Despite this success, women surgeon-scientists remained significantly underrepresented among SPIs and were 25% less likely to be an SPI (aRR, 0.75 [95% CI, 0.60-0.95] during the period 2016 to 2020).

CONCLUSIONS AND RELEVANCE

The findings of this cross-sectional study of NIH-funded surgeons suggest that women surgeons remained underrepresented among surgeon-scientists over a 25-year period despite early career success in receiving NIH funding. This is concerning and warrants further investigation to increase the distribution of NIH funding among women surgeon-scientists.

摘要

重要性

外科疾病约占全球疾病负担的 30%。在生物医学研究中,性别多样性对于产生以患者为中心的创新性外科研究至关重要。

目的

在 25 年期间,检查美国国立卫生研究院 (NIH) 分配给女性和男性外科医生科学家的生物医学研究资金在女性和男性外科医生科学家中的分布情况。

设计、环境和参与者:这项横断面研究使用了 NIH RePORTER(研究组合在线报告工具:支出和结果)数据库中的公开可用数据,该数据库针对的是在 1995 年至 2020 年期间担任主要研究者的女性和男性外科医生科学家。数据于 2022 年 1 月 20 日至 3 月 20 日之间检索。随着时间的推移,比较了学术外科医生中女性外科医生科学家的代表性与男性外科医生科学家的代表性。

主要结果和措施

通过 2 项指标检查了 NIH 对女性和男性外科医生科学家的资金分配情况:获得大额(即 R01 等价)赠款和作为总年度研究经费超过 750000 美元的超级主要研究者 (SPI)。统计分析于 2022 年 4 月 1 日至 8 月 31 日之间进行。

结果

在 1995 年至 2020 年期间,有 2078 名主要研究者外科医生获得了 NIH 的资助。在此期间,女性学术外科医生中外科医生科学家的比例保持不变(1995 年,792 名中的 14 名[1.8%]与 2020 年,3834 名中的 92 名[2.4%];P=.10)。与男性同行相比,女性外科医生科学家在职业生涯早期更早地获得了 NIH 的第一笔赠款(获得首次教职后的平均[SD]年数,8.8[6.2]与 10.8[7.9]年;P <.001),并且在 2016 年至 2020 年期间获得大额赠款的可能性相同(ARR,0.99[95%CI,0.95-1.03])。尽管取得了这一成功,但女性外科医生科学家在超级研究者中的代表性仍然明显不足,成为超级研究者的可能性低 25%(ARR,0.75[95%CI,0.60-0.95],2016 年至 2020 年期间)。

结论和相关性

这项对 NIH 资助的外科医生进行的横断面研究的结果表明,尽管女性外科医生在获得 NIH 资助方面在职业生涯早期取得了成功,但在 25 年内,女性外科医生在外科医生科学家中的代表性仍然不足。这令人担忧,需要进一步调查以增加 NIH 资助在女性外科医生科学家中的分配。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a5ce/10028489/4f02ad8e5041/jamanetwopen-e233630-g001.jpg

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