维生素 B 补充剂对老年人认知功能的影响：荟萃分析。

Effectiveness of vitamin-B supplements on cognition in older adults: A meta-analysis.

机构信息

Department of Geriatrics, The General Hospital of Western Theater Command, Sichuan 610083, China.

Department of Critical Care Medicine, The 942 Hospital of the PLA Joint Logistic Support Force, Ningxia 750000, China.

出版信息

Geriatr Nurs. 2023 May-Jun;51:143-149. doi: 10.1016/j.gerinurse.2023.02.019. Epub 2023 Mar 20.

DOI:10.1016/j.gerinurse.2023.02.019

PMID:36940509

Abstract

OBJECTIVES

We aimed to investigate the efficacy of B-vitamin and folic acid supplementation in slowing down cognitive function decline among older adults.

METHODS

We searched databases for trials comparing B-vitamin and folate supplementation versus placebo in older adults identified with or without impaired cognition.

RESULTS

23 articles were eligible and included in this meta-analysis. The mean difference (MD) in homocysteine levels was significant between the compared groups (MD:-4.52; 95%CI:-5.41 to 3.63, P < 0.001). However, the difference in the Mini-Mental State Examination (MMSE) was non-significant between the compared groups with or without cognitive impairment (MD:0.19; 95%CI: -0.148 to 0.531, P = 0.27), and (MD:0.04; 95%CI:-0.1 to 0.18, P = 0.59), respectively. The difference in Clinical Dementia Rating-sum of box (CDR-SOB) scores was non-significant (MD:-0.16; 95%CI:-0.49 to 0.18; P = 0.36).

CONCLUSIONS

B-vitamin and folate supplementations significantly reduced homocysteine levels. However, it failed to provide significant benefits over placebo in preventing or slowing the decline in cognitive function.

摘要

目的

我们旨在探究补充维生素 B 族和叶酸对于减缓老年人认知功能下降的效果。

方法

我们检索了数据库中比较维生素 B 族和叶酸补充剂与安慰剂在认知障碍或无认知障碍老年人中的疗效的试验。

结果

23 篇文章符合纳入标准并被纳入本次荟萃分析。相比安慰剂组，实验组的同型半胱氨酸水平的平均差值具有显著统计学意义（MD:-4.52；95%CI:-5.41 至 3.63，P<0.001）。然而，无论是否存在认知障碍，实验组在简易精神状态检查量表（MMSE）的评分差值均无统计学意义（MD:0.19；95%CI:-0.148 至 0.531，P=0.27）和（MD:0.04；95%CI:-0.1 至 0.18，P=0.59）。在临床痴呆评定量表总和评分（CDR-SOB）差值方面，差异也无统计学意义（MD:-0.16；95%CI:-0.49 至 0.18；P=0.36）。