Guangdong Key Laboratory for Biomedical Measurements and Ultrasound Imaging, National-Regional Key Technology Engineering Laboratory for Medical Ultrasound, School of Biomedical Engineering, Shenzhen University Medical School, Shenzhen, 518060, China.
Guangdong Key Laboratory for Biomedical Measurements and Ultrasound Imaging, National-Regional Key Technology Engineering Laboratory for Medical Ultrasound, School of Biomedical Engineering, Shenzhen University Medical School, Shenzhen, 518060, China; Shanghai Key Laboratory of Hydrogen Science & Center of Hydrogen Science, School of Materials Science and Engineering, Shanghai Jiao Tong University, Shanghai, 200240, China; Shenzhen Research Institute, Shanghai Jiao Tong University, Shenzhen, 518057, China.
Biomaterials. 2023 May;296:122090. doi: 10.1016/j.biomaterials.2023.122090. Epub 2023 Mar 13.
Therapeutic gas molecules have high tissue penetrability, but their sustainable supply and controlled release in deep tumor is a huge challenge. In this work, a concept of sonocatalytic full water splitting for hydrogen/oxygen immunotherapy of deep tumor is proposed, and a new kind of ZnS nanoparticles with a mesocrystalline structure (mZnS) is developed to achieve highly efficient sonocatalytic full water splitting for sustainable supply of H and O in tumor, achieving a high efficacy of deep tumor therapy. Mechanistically, locally generated hydrogen and oxygen molecules exhibit a tumoricidal effect as well as the co-immunoactivation of deep tumors through inducing the M2-to-M1 repolarization of intratumoral macrophages and the tumor hypoxia relief-mediated activation of CD8 T cells, respectively. The proposed sonocatalytic immunoactivation strategy will open a new window to realize safe and efficient treatment of deep tumors.
治疗性气体分子具有很高的组织穿透性，但在深部肿瘤中持续供应和控制其释放是一个巨大的挑战。在这项工作中，提出了一种用于深部肿瘤的氢/氧免疫治疗的声催化全水分解的概念，并开发了一种新型具有介晶结构的 ZnS 纳米粒子（mZnS），以实现高效的声催化全水分解，从而在肿瘤中可持续供应 H 和 O，实现深部肿瘤治疗的高效性。从机制上讲，局部产生的氢气和氧气分子通过诱导肿瘤内巨噬细胞的 M2 向 M1 再极化以及缓解肿瘤缺氧介导的 CD8 T 细胞激活，分别表现出肿瘤杀伤作用和深部肿瘤的共免疫激活作用。所提出的声催化免疫激活策略将为实现深部肿瘤的安全有效治疗开辟新的途径。
