Li Renwei, Huang Jing, Wei Yuhao, Wang Yusha, Lu Can, Liu Jifeng, Ma Xuelei
Department of Biotherapy, State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University, Chengdu, Sichuan, 610041, People's Republic of China.
Department of Medical Ultrasound, West China Hospital, Sichuan University, Chengdu, Sichuan, 610041, People's Republic of China.
Int J Nanomedicine. 2024 Dec 19;19:13615-13651. doi: 10.2147/IJN.S491573. eCollection 2024.
Macrophage is an important component in the tumor immune microenvironment, which exerts significant influence on tumor development and metastasis. Due to their dual nature of promoting and suppressing inflammation, macrophages can serve as both targets for tumor immunotherapy and tools for treating malignancies. However, the abundant infiltration of tumor-associated macrophages dominated by an immunosuppressive phenotype maintains a pro-tumor microenvironment, and engineering macrophages using nanotechnology to manipulate the tumor immune microenvironment represent a feasible approach for cancer immunotherapy. Additionally, considering the phagocytic and specifically tumor-targeting capabilities of M1 macrophages, macrophages manipulated through cellular engineering and nanotechnology, as well as macrophage-derived exosomes and macrophage membranes, can also become effective tools for cancer treatment. In conclusion, nanotherapeutics targeting macrophages remains immense potential for the development of macrophage-mediated tumor treatment methods and will further enhance our understanding, diagnosis, and treatment of various malignants.
巨噬细胞是肿瘤免疫微环境中的重要组成部分，对肿瘤的发生发展及转移具有重要影响。由于巨噬细胞具有促进和抑制炎症的双重特性，其既可以作为肿瘤免疫治疗的靶点，也可以作为治疗恶性肿瘤的工具。然而，以免疫抑制表型为主的肿瘤相关巨噬细胞大量浸润维持了肿瘤微环境，利用纳米技术改造巨噬细胞以调控肿瘤免疫微环境是癌症免疫治疗的一种可行方法。此外，鉴于M1巨噬细胞的吞噬和特异性肿瘤靶向能力，通过细胞工程和纳米技术改造的巨噬细胞以及巨噬细胞衍生的外泌体和巨噬细胞膜也可成为癌症治疗的有效工具。总之，靶向巨噬细胞的纳米治疗在巨噬细胞介导的肿瘤治疗方法开发方面仍具有巨大潜力，并将进一步加深我们对各种恶性肿瘤的认识、诊断和治疗。
