污染农田土壤中金属（类）的空间分布、健康风险和细胞毒性：镉在人胃细胞损伤中的作用。
The spatial distribution, health risk, and cytotoxicity of metal(loid)s in contaminated field soils: The role of Cd in human gastric cells damage.
机构信息
Yunnan Province Innovative Research Team of Environmental pollution, Food Safety, and Human Health, Institute of Environmental Remediation and Human Health, School of Ecology and Environment, Southwest Forestry University, Kunming 650224, China.
Yunnan Province Innovative Research Team of Environmental pollution, Food Safety, and Human Health, Institute of Environmental Remediation and Human Health, School of Ecology and Environment, Southwest Forestry University, Kunming 650224, China; Guangdong Key Laboratory of Contaminated Environmental Management and Remediation, Guangdong Provincial Academy of Environmental Science, Guangzhou 510000, China.
出版信息
Sci Total Environ. 2023 Jun 20;878:162942. doi: 10.1016/j.scitotenv.2023.162942. Epub 2023 Mar 20.
The spatial distribution and pollution level of heavy metal(loid)s in soil (0-6 m) from a typical industrial region in Jiangmen City, Southeast China was investigated. Their bioaccessibility, health risk, and human gastric cytotoxicity in topsoil were also evaluated using an in vitro digestion/human cell model. The average concentrations of Cd (87.52 mg/kg), Co (106.9 mg/kg), and Ni (1007 mg/kg) exceeded the risk screening values. The distribution profiles of metal(loid)s showed a downward migration trend to reach a depth of 2 m. The highest contamination was found in topsoil (0-0.5 m), with the concentrations of As, Cd, Co, and Ni being 46.98, 348.28, 317.44, and 2395.60 mg/kg, respectively, while Cd showed the highest bioaccessibility in the gastric phase (72.80 %), followed by Co (21.08 %), Ni (18.27 %), and As (5.26 %) and unacceptable carcinogenic risk. Moreover, the gastric digesta of topsoil suppressed the cell viability and triggered cell apoptosis, evidenced by disruption of mitochondrial transmembrane potential and increase of Cytochrome c (Cyt c) and Caspases 3/9 mRNA expression. Bioaccessible Cd in topsoil was responsible for those adverse effects. Our data suggest the importance to reduce Cd in the soil to decrease its adverse impacts on the human stomach.
本研究调查了中国东南部江门市典型工业区土壤（0-6 m）中重金属（类金属）的空间分布和污染水平。还采用体外消化/人细胞模型评估了它们在表土中的生物可给性、健康风险和人类胃细胞毒性。Cd（87.52 mg/kg）、Co（106.9 mg/kg）和 Ni（1007 mg/kg）的平均浓度均超过了风险筛选值。金属（类金属）的分布特征表现出向下迁移的趋势，达到 2 m 的深度。在表土（0-0.5 m）中发现了最高的污染程度，As、Cd、Co 和 Ni 的浓度分别为 46.98、348.28、317.44 和 2395.60 mg/kg，而 Cd 在胃相中具有最高的生物可给性（72.80%），其次是 Co（21.08%）、Ni（18.27%）和 As（5.26%），同时还存在不可接受的致癌风险。此外，表土的胃消化物抑制了细胞活力并引发了细胞凋亡，这一点可从线粒体跨膜电位的破坏以及 Cytochrome c（Cyt c）和 Caspases 3/9 mRNA 表达的增加得到证明。表土中具有生物可给性的 Cd 是造成这些不利影响的原因。我们的数据表明，减少土壤中的 Cd 对于降低其对人类胃的不良影响非常重要。
Zotero 插件