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研究支持从酒精和其他物质使用障碍中康复的神经行为差异。

Examining neurobehavioral differences that support success in recovery from alcohol and other substance use disorders.

机构信息

Department of Human Nutrition, Foods, and Exercise, Virginia Tech, VA, USA.

Department of Human Nutrition, Foods, and Exercise, Virginia Tech, VA, USA; Fralin Biomedical Research Institute at VTC, VA, USA; School of Neuroscience, Virginia Tech, VA, USA.

出版信息

J Subst Use Addict Treat. 2023 May;148:209007. doi: 10.1016/j.josat.2023.209007. Epub 2023 Mar 20.

Abstract

OBJECTIVE

Substance use disorders (SUDs) are brain disorders associated with impairments resulting from the recurrent use of alcohol, drugs, or both. Though recovery is possible, SUDs are chronic, relapsing-remitting disorders, with estimates of SUD relapse at 40-60%. Currently, we know little about the mechanisms underlying successful recovery processes and whether substance-specific mechanisms exist. The current study sought to examine delay discounting (a measure of future valuation), executive skills, abstinence duration, and health behaviors in a population of individuals in recovery from alcohol, stimulants, opioids, and other substances.

METHODS

In this observational study, we utilized a cohort of individuals (n = 238) from the International Quit and Recovery Registry, an online registry for those in recovery from SUDs around the world. We assessed delay discounting through a neurobehavioral task, and assessed abstinence duration, executive skills, and engagement in positive health behaviors through self-report measures.

RESULTS

We found that delay discounting, executive skills, and engagement in positive health behaviors were similar among individuals in recovery from different substances. Abstinence duration was associated with delay discounting and engagement in health behaviors. Additionally, executive skills and engagement in health behaviors were positively associated.

CONCLUSION

These findings suggest that common behavioral mechanisms support recovery from misuse of various substances. As both delay discounting and executive skills are dependent upon executive brain centers, such as the prefrontal cortex, strategies that target executive functioning, such as episodic future thinking, meditation, or exercise, may be efficient strategies for optimizing recovery from SUDs.

摘要

目的

物质使用障碍(SUD)是一种与反复使用酒精、药物或两者同时使用相关的大脑障碍,会导致认知功能障碍。尽管有可能康复,但 SUD 是一种慢性、复发性疾病,SUD 复发的估计值为 40-60%。目前,我们对成功康复过程的机制以及是否存在物质特异性机制知之甚少。本研究旨在研究从酒精、兴奋剂、阿片类药物和其他物质中康复的人群中的延迟折扣(一种衡量未来价值的方法)、执行技能、禁欲持续时间和健康行为。

方法

在这项观察性研究中,我们利用了国际戒烟与康复登记处(一个全球范围内康复治疗物质使用障碍的在线登记处)中的一组个体(n=238)。我们通过神经行为任务评估延迟折扣,通过自我报告评估禁欲持续时间、执行技能和参与积极的健康行为。

结果

我们发现,来自不同物质滥用康复者的个体之间,延迟折扣、执行技能和参与积极健康行为相似。禁欲持续时间与延迟折扣和参与健康行为有关。此外,执行技能和参与健康行为呈正相关。

结论

这些发现表明,共同的行为机制支持各种物质滥用的康复。由于延迟折扣和执行技能都依赖于执行大脑中枢,如前额叶皮层,因此针对执行功能的策略,如情景性未来思维、冥想或锻炼,可能是优化 SUD 康复的有效策略。

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