Haum Magda, Kellnar Antonia, Thienel Manuela, Lackermair Korbinian
Department of Medicine I, Munich University Hospital, Ludwig-Maximilian-University, Munich, Germany; DZHK (German Centre for Cardiovascular Research), Partner Site Munich Heart Alliance, Germany.
Department of Medicine I, Munich University Hospital, Ludwig-Maximilian-University, Munich, Germany.
Pharmacol Ther. 2023 Apr;244:108388. doi: 10.1016/j.pharmthera.2023.108388. Epub 2023 Mar 20.
Cardiac arrhythmias are a common and potentially serious cardiovascular disorders that affect both men and women. However, there is evidence to suggest that there may be sex-related differences in the prevalence, clinical presentation, and management of cardiac arrhythmias. Hormonal and cellular factors may play a role in these sex-specific differences. In addition, there are differences in the types of arrhythmias that men and women experience, with men more likely to experience ventricular arrhythmias and women more likely to experience supraventricular arrhythmias. The management of cardiac arrhythmias also differs between men and women. For example, some studies have found that women are less likely to receive appropriate treatment for arrhythmias and are more likely to have adverse outcomes following treatment. Despite these sex-related differences, the majority of research on cardiac arrhythmias has been conducted in men, and there is a need for more research to specifically examine the differences between men and women. This is especially important given that the prevalence of cardiac arrhythmia is increasing, and it is essential to understand how to effectively diagnose and treat these conditions in both men and women. In this review, we examine the current understanding of sex-related differences in cardiac arrhythmias. We also review the available data on sex-specific management strategies for cardiac arrhythmias and highlight areas of future research.
心律失常是一种常见且可能严重的心血管疾病，影响着男性和女性。然而，有证据表明，心律失常的患病率、临床表现和管理可能存在性别差异。激素和细胞因素可能在这些性别特异性差异中起作用。此外，男性和女性经历的心律失常类型也有所不同，男性更易发生室性心律失常，而女性更易发生室上性心律失常。心律失常的管理在男性和女性之间也存在差异。例如，一些研究发现，女性接受心律失常适当治疗的可能性较小，且治疗后出现不良后果的可能性更大。尽管存在这些性别差异，但大多数关于心律失常的研究是在男性中进行的，因此需要更多研究来专门探讨男性和女性之间的差异。鉴于心律失常的患病率正在上升，了解如何有效诊断和治疗男性和女性的这些疾病至关重要，这一点尤为重要。在本综述中，我们研究了目前对心律失常性别差异的认识。我们还回顾了关于心律失常性别特异性管理策略的现有数据，并突出了未来研究的领域。
