Suppr超能文献

脉冲电场消融过程——金属支架不同形状(材料)对消融效果影响的研究

Pulsed electric field ablation process-a study of the effect of different shapes (materials) of metal stents on the ablation effect.

作者信息

Wang Zhen, Liang Ming, Sun Jingyang, Zhang Jie, Li Yunhao, Xuan Fengqi, Han Yaling

机构信息

College of Medicine and Biological Information Engineering, Northeastern University, Shenyang, China.

Department of Cardiology, General Hospital of Northern Theater Command, Shenyang, China.

出版信息

Front Cardiovasc Med. 2025 May 20;12:1603410. doi: 10.3389/fcvm.2025.1603410. eCollection 2025.

Abstract

BACKGROUND

Arrhythmias are a common group of cardiovascular diseases, and in recent years, pulsed electric field ablation technology has made great progress in the treatment of arrhythmias. However, the effect of different materials and shapes of cardiac stents on the ablation effect at the target site during epicardial ablation has not been effectively studied.

METHODS

The ablation targeting position was modeled and simplified, the ablation catheter and cardiac stent were restored in real size, and the ablation region was modeled in three dimensions using a computer. Multi-model cardiac stents were established and different materials were added to different stents, and the ablation region was effectively evaluated with a field strength of 1,000 V/cm as the contour.

RESULTS

The ablative electric field was present only at the ablation targeting site. In the computational simulation, the effective ablation width caused by the simplified metal stent was not significantly different from that of the real stent (the maximum difference in ablation width was 0.34 mm). The variation of the effective ablation area caused by different metals was small (for example, the ablation catheter was 0.5 mm away from the metal stent, and the width of the effective ablation area ranged from 9.79 mm to 10.13 mm). The maximum temperature change at the targeting site caused by the simplified stent of the scaffold was small (the maximum temperature after ablation was 43.88°C, and the maximum temperature after ablation of the real scaffold was 45.19°C).

CONCLUSION

The simulation results show that the width of the targeted ablation area does not change greatly due to the shape and material of the metal stent, and the simplified metal stent model can effectively predict the effective ablation area. The metal stent has a certain warming effect on the ablation area, and the warming phenomenon of the real stent is more intense than that of the simplified stent, but this temperature change does not cause thermal damage to the targeting site.

摘要

背景

心律失常是一组常见的心血管疾病,近年来,脉冲电场消融技术在心律失常治疗方面取得了很大进展。然而,不同材料和形状的心脏支架在心外膜消融过程中对靶部位消融效果的影响尚未得到有效研究。

方法

对消融靶点位置进行建模和简化,按实际尺寸还原消融导管和心脏支架,利用计算机对消融区域进行三维建模。建立多种型号的心脏支架,在不同支架中添加不同材料,以场强1000 V/cm为轮廓对消融区域进行有效评估。

结果

消融电场仅出现在消融靶点部位。在计算模拟中,简化金属支架引起的有效消融宽度与真实支架相比无显著差异(消融宽度最大差值为0.34 mm)。不同金属引起的有效消融面积变化较小(例如,消融导管距金属支架0.5 mm时,有效消融面积宽度在9.79 mm至10.13 mm之间)。支架简化模型引起的靶点部位最大温度变化较小(消融后最高温度为43.88°C,真实支架消融后最高温度为45.19°C)。

结论

模拟结果表明,金属支架的形状和材料对靶向消融区域宽度影响不大,简化金属支架模型可有效预测有效消融面积。金属支架对消融区域有一定的升温作用,真实支架的升温现象比简化支架更明显,但这种温度变化不会对靶点部位造成热损伤。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1661/12131867/e05fdd06b1d0/fcvm-12-1603410-g001.jpg

文献检索

告别复杂PubMed语法,用中文像聊天一样搜索,搜遍4000万医学文献。AI智能推荐,让科研检索更轻松。

立即免费搜索

文件翻译

保留排版,准确专业,支持PDF/Word/PPT等文件格式,支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述,25分钟生成高质量综述,智能提取关键信息,辅助科研写作。

立即免费体验