Frank T H, Blaumanis O R, Gibbs R K, Wells R K
Perinatronics Medical Systems, Inc., Crofton, Maryland 21114-2141.
J Electrocardiol. 1987 Oct;20 Suppl:108-13.
There has long been an interest in noninvasively monitoring the fetal electrocardiogram (ECG). In the past twenty years a clinical need has developed to monitor the instantaneous fetal heart rate (FHR) and changes in the heart rate from one beat to the next, i.e., beat-to-beat FHR variability as well as an interest in understanding the development of cardiac arrhythmias. The purpose of this paper is to present initial results obtained from an Electrocardiographic Adaptive Processor (EAP) to noninvasively monitor in real-time continuous tracings of the fetal ECG, FHR, and FHR variability. Twenty-five sets of noninvasive fetal ECG data were collected from pregnant subjects during the third trimester of pregnancy using maternal abdominal paste-on electrodes. The fetal QRS amplitude and shape varied from 5 to 30 microvolts with fetal position, gestational age, and relative electrode configuration. Results have been obtained in three specific areas: 1) The development and initial testing of a microprocessor based Electrocardiographic Adaptive Processor (EAP) implemented as an FHR monitor has been completed. The EAP has been implemented to adaptively cancel, in real-time, the maternal ECG component from maternal abdominal ECG leads to provide a continuous tracing of the fetal ECG complex, or FHR and FHR variability. 2) Maternal and thoracic ECG data stored on computer disk were used to test the adaptive techniques to cancel the strong interfering maternal ECG. Studies continue to effectively reduce background electromyographic (EMG) noise. 3) Tracings of the fetal QRS complex, instantaneous FHR, and short term FHR variability have been obtained in real-time.(ABSTRACT TRUNCATED AT 250 WORDS)
长期以来,人们一直对无创监测胎儿心电图(ECG)感兴趣。在过去的二十年里,临床上产生了监测胎儿瞬时心率(FHR)以及逐搏心率变化(即逐搏FHR变异性)的需求,同时也对了解心律失常的发展情况产生了兴趣。本文的目的是展示从心电图自适应处理器(EAP)获得的初步结果,以无创方式实时连续监测胎儿心电图、FHR及FHR变异性。在妊娠晚期,使用母体腹部粘贴电极从孕妇身上收集了25组无创胎儿心电图数据。胎儿QRS波的幅度和形态会因胎儿位置、孕周和相对电极配置而在5至30微伏之间变化。已在三个特定领域取得了结果:1)已完成基于微处理器的心电图自适应处理器(EAP)作为FHR监测器的开发和初步测试。EAP已被实现为实时自适应消除母体腹部心电图导联中的母体心电图成分,以提供胎儿心电图复合波、FHR及FHR变异性的连续记录。2)存储在计算机磁盘上的母体和胸部心电图数据被用于测试消除强烈干扰的母体心电图的自适应技术。研究继续有效降低背景肌电图(EMG)噪声。3)已实时获得胎儿QRS复合波、瞬时FHR及短期FHR变异性的记录。(摘要截选至250字)