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学术转诊中心剖宫产瘢痕部位妊娠的管理:病例系列。

Management of cesarean scar ectopic pregnancies at an academic referral center: A case series.

机构信息

Department of Obstetrics and Gynecology, University of California, Davis, Sacramento, CA, USA.

Department of Obstetrics and Gynecology, University of California, Davis, Sacramento, CA, USA.

出版信息

Contraception. 2023 Jul;123:110021. doi: 10.1016/j.contraception.2023.110021. Epub 2023 Mar 20.

Abstract

OBJECTIVES

To describe treatment and outcomes of patients with confirmed cesarean scar ectopic pregnancy (CSEP) at a tertiary referral center.

STUDY DESIGN

We reviewed a deidentified family planning clinical database for patients seen by our subspecialty service for CSEP from January 2017 through December 2021 in this case series. We extracted referral information, final diagnosis, management, and outcome measures including estimated blood loss, secondary procedures, and treatment complications.

RESULTS

Of 57 cases referred for suspected CSEPs, 23 (40%) had confirmed diagnoses; one additional case was diagnosed during clinic evaluation for early pregnancy loss. Most (n = 50 [88%]) referrals occurred in the last 2 years of the 5-year study period. Of 24 confirmed CSEP cases, eight were pregnancy losses at the time of diagnosis. Fourteen cases were ≤50 days gestation or gestational size (7 [50%] pregnancy losses) and 10 >50 days gestation (range 39-66 days). We treated all 14 patients ≤50 days primarily with suction aspiration under ultrasound guidance in an operating room with no complications and estimated blood loss of 14 ± 10 mL. Of the 10 patients>50 days (maximum 66 days), seven were managed with primary aspiration of which five were uncomplicated. We treated one patient (57 days) had primary intrauterine double-catheter balloon with immediate hemorrhage requiring uterine artery embolization followed by an uncomplicated suction aspiration.

CONCLUSIONS

Patients with confirmed CSEPs at 50 days or less gestation or gestational size can likely be primarily treated with suction aspiration with low risk for significant adverse outcomes. Treatment success and complications are directly related to gestational age at treatment.

IMPLICATIONS

Ultrasound-guided suction aspiration monotherapy should be considered for primary CSEP treatment up to 50 days and, with continued experience, may be reasonable beyond 50 days gestation. Invasive treatments or those that require multiple days and visits, such as methotrexate or balloon catheters, are not necessary for early CSEPs.

摘要

目的

描述在一家三级转诊中心确诊的剖宫产瘢痕部位妊娠(CSEP)患者的治疗和结局。

研究设计

本病例系列研究回顾了 2017 年 1 月至 2021 年 12 月期间,我们的妇产科专科服务对 CSEP 患者的匿名计划生育临床数据库。我们提取了转诊信息、最终诊断、管理和结局指标,包括估计出血量、二次手术和治疗并发症。

结果

57 例疑似 CSEP 患者中,23 例(40%)确诊;1 例在早期妊娠丢失的就诊时确诊。在 5 年研究期间的最后 2 年,大多数(n=50[88%])患者转诊。24 例确诊的 CSEP 病例中,8 例在诊断时为妊娠丢失。14 例妊娠<50 天或妊娠大小(7[50%]妊娠丢失),10 例>50 天(范围 39-66 天)。我们对所有 14 例≤50 天的患者主要在手术室超声引导下使用吸引术治疗,无一例发生并发症,估计出血量为 14±10ml。在 10 例>50 天(最大 66 天)的患者中,7 例采用初次吸引术治疗,其中 5 例无并发症。我们对一名 57 天的患者进行了原发性宫内双导管球囊治疗,立即发生出血,需要行子宫动脉栓塞治疗,随后行无并发症的吸引术。

结论

妊娠 50 天或以下或妊娠大小的确诊 CSEP 患者可能主要通过吸引术治疗,不良结局风险较低。治疗成功和并发症与治疗时的孕龄直接相关。

意义

对于妊娠 50 天或以下的原发性 CSEP,超声引导下的吸引术治疗应作为首选,随着经验的不断积累,对于妊娠 50 天以上的患者也可能是合理的。对于早期 CSEP,不需要使用侵入性治疗或需要多天和多次就诊的治疗方法,如甲氨蝶呤或球囊导管。

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