[肠道微生物群失调与骨关节炎关系的研究进展]
[Research progress on the relationship between gut microbiota dysbiosis and osteoarthritis].
作者信息
Jiang Shenghu, Shen Bin
机构信息
Orthopedic Research Institute, Department of Orthopedics, West China Hospital, Sichuan University, Chengdu Sichuan, 610041, P. R. China.
出版信息
Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi. 2023 Mar 15;37(3):371-376. doi: 10.7507/1002-1892.202212037.
OBJECTIVE
To introduce the research progress on the relationship between gut microbiota dysbiosis and osteoarthritis (OA), focus on the possible mechanism of gut microbiota dysbiosis promoting OA, and propose a new therapeutic direction.
METHODS
The domestic and foreign research literature on the relationship between gut microbiota dysbiosis and OA was reviewed. The role of the former in the occurrence and development of OA and the new ideas for the treatment of OA were summarized.
RESULTS
The gut microbiota dysbiosis promotes the development of OA mainly in three aspects. First, the gut microbiota dysbiosis destroys intestinal permeability and causes low-grade inflammation, which aggravate OA. Secondly, the gut microbiota dysbiosis promotes the development of OA through metabolic syndrome. Thirdly, the gut microbiota dysbiosis is involved in the development of OA by regulating the metabolism and transport of trace elements. Studies have shown that improving gut microbiota dysbiosis by taking probiotics and transplanting fecal microbiota can reduce systemic inflammation and regulate metabolic balance, thus treating OA.
CONCLUSION
Gut microbiota dysbiosis is closely related to the development of OA, and improving gut microbiota dysbiosis can be an important idea for OA treatment.
目的
介绍肠道微生物群失调与骨关节炎（OA）关系的研究进展，重点关注肠道微生物群失调促进OA的可能机制，并提出新的治疗方向。
方法
回顾国内外关于肠道微生物群失调与OA关系的研究文献。总结前者在OA发生发展中的作用以及OA治疗的新思路。
结果
肠道微生物群失调主要从三个方面促进OA的发展。首先，肠道微生物群失调破坏肠道通透性并引起低度炎症，从而加重OA。其次，肠道微生物群失调通过代谢综合征促进OA的发展。第三，肠道微生物群失调通过调节微量元素的代谢和转运参与OA的发展。研究表明，通过服用益生菌和移植粪便微生物群来改善肠道微生物群失调可减轻全身炎症并调节代谢平衡，从而治疗OA。
结论
肠道微生物群失调与OA的发展密切相关，改善肠道微生物群失调可能是OA治疗的一个重要思路。
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