Mogoş Gabriel Florin Răzvan, Manciulea Profir Monica, Enache Robert-Mihai, Pavelescu Luciana Alexandra, Popescu Roşu Oana Alexandra, Cretoiu Sanda Maria, Marinescu Ileana
Department of Surgery, University of Medicine and Pharmacy of Craiova, 200349 Craiova, Romania.
Department of Morphological Sciences, Cell and Molecular Biology and Histology, Carol Davila University of Medicine and Pharmacy, 050474 Bucharest, Romania.
Nutrients. 2025 Jun 21;17(13):2071. doi: 10.3390/nu17132071.
The gut microbiota plays a crucial role in early-life development, influencing various aspects of health and disease. Dysbiosis, an imbalance in the gut microbiota, has been linked to multiple health conditions, including allergies, asthma, and obesity. In early life, the gut microbiota plays a key role in the development and maturation of the immune system. Probiotics, live microorganisms that confer health benefits when administered in adequate amounts, have emerged as a potential treatment approach for dysbiosis in early life. Dysbiosis can alter the resistance to pathogens, promoting atopic diseases, food sensitization, and infections such as necrotizing enterocolitis (NEC). Probiotics have been shown to modulate the composition and function of the gut microbiota in the perinatal and infant periods. They can increase the abundance of beneficial bacteria, such as and , and reduce the levels of potentially harmful bacteria. Not all probiotics are created equal. The effects of probiotics can vary depending on the specific strain used. Probiotics have also been investigated for their potential benefits in other areas of infant health, such as reducing the risk of respiratory infections and improving growth and development. This review aims to analyze the current data in the literature and to evaluate the health benefits of probiotic administration in early life. Several studies have investigated the use of probiotics in preventing or treating allergic diseases, such as eczema and food allergies. While some studies have shown promising results, more research is needed to fully understand the benefits and risks of probiotics in early life. In conclusion, using probiotics to prevent dysbiosis-related conditions may be considered a method of 'programming' the individual for optimal health maintenance.
肠道微生物群在生命早期发育中起着至关重要的作用,影响着健康和疾病的各个方面。肠道微生物群失调,即肠道微生物群的失衡,与多种健康状况有关,包括过敏、哮喘和肥胖。在生命早期,肠道微生物群在免疫系统的发育和成熟中起关键作用。益生菌是适量施用时能带来健康益处的活微生物,已成为治疗生命早期肠道微生物群失调的一种潜在方法。肠道微生物群失调会改变对病原体的抵抗力,引发特应性疾病、食物过敏和坏死性小肠结肠炎(NEC)等感染。已表明益生菌可在围产期和婴儿期调节肠道微生物群的组成和功能。它们可以增加有益细菌的丰度,如 和 ,并降低潜在有害细菌的水平。并非所有益生菌都是一样的。益生菌的效果可能因所使用的特定菌株而异。益生菌在婴儿健康的其他领域的潜在益处也已得到研究,如降低呼吸道感染风险和改善生长发育。本综述旨在分析文献中的现有数据,并评估生命早期施用益生菌的健康益处。多项研究调查了益生菌在预防或治疗过敏性疾病(如湿疹和食物过敏)中的应用。虽然一些研究显示出了有前景的结果,但仍需要更多研究来充分了解益生菌在生命早期的益处和风险。总之,使用益生菌预防与肠道微生物群失调相关的疾病可能被视为一种为个体“编程”以维持最佳健康的方法。