膀胱癌患者抗氧化状态与癌症分期和分级的关系。
Antioxidant status in patients with bladder cancer regarding cancer stage and grade.
作者信息
Lepara Zahid, Alić Jasmin, Lepara Orhan, Spahović Hajrudin, Fajkić Almir
机构信息
Urology Clinic, Clinical Center University of Sarajevo, Bolnička 25, 71 000 Sarajevo, Bosnia and Herzegovina.
Department of Physiology, Faculty of Medicine, University of Sarajevo, Čekaluša 90, 71 000 Sarajevo, Bosnia and Herzegovina.
出版信息
Asian J Urol. 2023 Apr;10(2):182-188. doi: 10.1016/j.ajur.2021.12.008. Epub 2022 Aug 3.
OBJECTIVE
The imbalance of antioxidants and pro-oxidants plays a crucial role in the carcinogenesis of bladder cancer (BC). This study aimed to evaluate serum antioxidant status in patients with BC and determine its potential use in the diagnosis and progression potential considerations following histopathological assessment.
METHODS
A cross-sectional study included 90 patients with BC, divided into Ta, T1, and T2-T4 stage subgroups, and according to cancer progression potential, into low-grade (LG) and high-grade (HG) subgroups. The control group (CG) included 30 healthy volunteers. Antioxidant status was determined using the spectrophotometric method and standard laboratory tests.
RESULTS
Serum superoxide dismutase activity was significantly higher in BC patients regarding cancer stage in comparison to the CG (<0.001). Catalase activity was highest in T2-T4 subgroup and was significantly higher compared to the Ta (<0.01) and T1 (<0.05) subgroups. Serum albumin level was significantly lower in the BC group compared to the CG (<0.001). In addition, it was significantly lower in T2-T4 subgroup compared to T1 and Ta subgroups (<0.01). A significant negative correlation was found between tumor size and serum albumin level only (=-0.386, <0.01). Catalase activity was higher in HG subgroup (=0.009), while bilirubin level was higher in LG subgroup (=0.035). The optimal cut-off value of catalase activity in differentiating patients with LG and HG BC subgroups was ≥11.96 IU/L, and the specificity and sensitivity were 51.1% and 82.2%, respectively. Bilirubin level, for a calculated optimal cut-off value of ≥11.95 μmol/L, had a specificity of 44.1% and sensitivity of 80.0%.
CONCLUSION
More invasive stages of BC with greater progression potential are associated with an increase in enzymatic antioxidant activity and a decrease in non-enzymatic antioxidant capacity. It may suggest a possible role of antioxidants in the prediction and monitoring of illness trajectory.
目的
抗氧化剂与促氧化剂之间的失衡在膀胱癌（BC）的致癌过程中起着关键作用。本研究旨在评估BC患者的血清抗氧化状态，并确定其在组织病理学评估后的诊断及进展潜力考量中的潜在用途。
方法
一项横断面研究纳入了90例BC患者，分为Ta、T1以及T2 - T4期亚组，并根据癌症进展潜力分为低级别（LG）和高级别（HG）亚组。对照组（CG）包括30名健康志愿者。使用分光光度法和标准实验室检测来确定抗氧化状态。
结果
与CG相比，BC患者血清超氧化物歧化酶活性在癌症分期方面显著更高（<0.001）。过氧化氢酶活性在T2 - T4亚组中最高，与Ta亚组（<0.01）和T1亚组（<0.05）相比显著更高。BC组血清白蛋白水平与CG相比显著更低（<0.001）。此外，与T1和Ta亚组相比，T2 - T4亚组中血清白蛋白水平显著更低（<0.01）。仅在肿瘤大小与血清白蛋白水平之间发现显著负相关（=-0.386，<0.01）。HG亚组中过氧化氢酶活性更高（=0.009），而LG亚组中胆红素水平更高（=0.035）。区分LG和HG BC亚组患者时，过氧化氢酶活性的最佳截断值为≥11.96 IU/L，特异性和敏感性分别为51.1%和82.2%。胆红素水平在计算出的最佳截断值≥11.95 μmol/L时，特异性为44.1%，敏感性为80.0%。
结论
具有更大进展潜力的BC侵袭性更强阶段与酶促抗氧化活性增加和非酶促抗氧化能力降低相关。这可能提示抗氧化剂在疾病轨迹预测和监测中可能发挥的作用。
Zotero 插件