Popov Hristo, Koleva Tatiana, Stoyanov George S
General and Clinical Pathology, Forensic Medicine and Deontology, Medical University of Varna, Varna, BGR.
Nephrology, St. Marina University Hospital, Varna, BGR.
Cureus. 2023 Feb 16;15(2):e35051. doi: 10.7759/cureus.35051. eCollection 2023 Feb.
Henoch-Schönlein purpura (HSP) is the most common vasculitis in childhood, presenting with purpura, predominantly of the lower extremities and occasionally with renal involvement as well. Although associated with childhood, HSP, although rarely, can also develop in adults as well. Here we present a patient in his sixties, presenting with a myriad of rash units on his lower extremities, including bullous ones, and a constellation of chronic kidney failure. Skin and renal biopsy specimens revealed morphological changes and immune depositions representative of HSP. Despite treatment, the patient's kidney failure slowly progressed, and he expired eight months after his presentation due to associated complications. Although rare, the bullous form of HSP can be viewed as a more aggressive form of the disease, as seen by the presentation constellation and rapid progression in our case.
过敏性紫癜（HSP）是儿童最常见的血管炎，表现为紫癜，主要出现在下肢，偶尔也会累及肾脏。尽管与儿童期相关，但HSP虽然罕见，也可在成人中发生。在此，我们报告一位60多岁的患者，其下肢出现大量皮疹，包括大疱性皮疹，并伴有一系列慢性肾衰竭症状。皮肤和肾脏活检标本显示出具有HSP特征的形态学改变和免疫沉积。尽管进行了治疗，患者的肾衰竭仍缓慢进展，在就诊8个月后因相关并发症死亡。尽管罕见，但从我们病例的表现和快速进展来看，大疱性HSP可被视为该病更具侵袭性的一种形式。
