Borch-Iohnsen B, Nilssen K J
Institute for Nutrition Research, School of Medicine, University of Oslo, Norway.
J Nutr. 1987 Dec;117(12):2072-8. doi: 10.1093/jn/117.12.2072.
Changes in liver iron concentration in relation to seasonal body weight variations and food iron intake have been investigated in 77 Svalbard reindeer by chemical and histological methods. During the winter season the body weight decreased about 43% in females and 39% in males. Liver weight was reduced about 65% in both sexes. The liver iron concentration showed little or no difference between the sexes and was 29 +/- 13 mg iron/100 g wet weight in the autumn. The concentration increased in late winter to 291 +/- 52 mg iron/100 g in animals eating iron-rich forage plants, and to 165 +/- 92 mg iron/100 g in animals eating forage plants with a normal iron content. Starving animals with a very high iron concentration of the rumen content usually had massive siderosis in both parenchymal and nonparenchymal cells of the liver. In contrast, siderosis was restricted to nonparenchymal cells in starving animals with normal rumen iron concentration. Transferrin saturation was significantly higher in animals eating iron-rich forage plants than in those eating forage plants with a normal content. Therefore it is proposed that seasonal liver siderosis is a result of a) translocation of iron from catabolized blood and lean tissue that is recovered in nonparenchymal cells and b) high uptake of food iron with deposition in the parenchymal cells.
通过化学和组织学方法，对77只斯瓦尔巴驯鹿肝脏铁浓度与季节性体重变化及食物铁摄入量之间的关系进行了研究。在冬季，雌性驯鹿体重下降约43%，雄性下降约39%。两性肝脏重量均减少约65%。肝脏铁浓度在两性之间几乎没有差异，秋季时为29±13毫克铁/100克湿重。在冬季后期，食用富含铁的饲料植物的动物肝脏铁浓度增至291±52毫克铁/100克，而食用铁含量正常的饲料植物的动物肝脏铁浓度增至165±92毫克铁/100克。瘤胃内容物铁浓度极高的饥饿动物，其肝脏实质细胞和非实质细胞通常都有大量铁沉积。相比之下，瘤胃铁浓度正常的饥饿动物的铁沉积仅限于非实质细胞。食用富含铁的饲料植物的动物的转铁蛋白饱和度明显高于食用铁含量正常的饲料植物的动物。因此，有人提出季节性肝脏铁沉积是以下原因导致的：a）来自分解代谢的血液和瘦组织中的铁转移，这些铁在非实质细胞中重新获得；b）食物中铁的高摄入量以及在实质细胞中的沉积。
