Dey Mansi, Grover Kriti, Arora Siddharth, Agarwal Arjun, Garg Cheena, Mishra Bibhu Prasad, Sharma Harshad
Rohilkhand Medical College and Hospital, Bareilly, Uttar Pradesh India.
Hi-Tech Dental College and Hospital, Bhubaneswar, Odisha India.
Indian J Surg Oncol. 2024 Dec;15(4):909-917. doi: 10.1007/s13193-024-02011-y. Epub 2024 Jul 2.
Conventional oral squamous cell carcinoma (OSCC) is one of the most common cancers of the head and neck region. However, histopathological variants of conventional oral squamous cell carcinoma also exist, which range from highly aggressive to those with good prognosis. Here, we present a case series of different histopathological variants of conventional OSCC treated at our institute. A retrospective chart review was performed to search for squamous cell carcinoma of the oral cavity, which were operated at Rohilkhand Cancer Institute, Bareilly, Uttar Pradesh, India, from August 2018 till December 2023. Electronic database was searched for this purpose, and the histopathological variants of oral squamous cell carcinoma that underwent curative intent surgery including neck dissection, with or without adjuvant treatment were included in the form of case series. Clinico-pathological details of the histopathological variants were recorded and assessed. Treatment given and the status of the patients after the treatment were also noted wherever possible. A total of 421 cases of oral squamous cell carcinoma (OSCC) treated at our institute from August 2018 till December 2023 were identified. Out of these, there were 408 cases (97%) of conventional OSCC, while the remaining 13(3.1%) were the rare histopathological variants of conventional OSCC, which included 2 cases (0.5%) of acantholytic squamous cell carcinoma (ASCC), 7 cases (1.7%) of sarcomatoid squamous cell carcinoma (SSCC), and 4 cases (1%) of verrucous squamous cell carcinoma (VSCC). Both ASCC and SSCC showed poor prognosis despite adjuvant treatment in the form of CTRT, while VSCC showed good prognosis despite not receiving any adjuvant treatment. SSCC and ASCC are highly aggressive tumors, while VSCC has a good prognosis.
传统口腔鳞状细胞癌（OSCC）是头颈部最常见的癌症之一。然而，传统口腔鳞状细胞癌也存在组织病理学变异，其侵袭性从高到预后良好不等。在此，我们展示了我院治疗的一系列传统OSCC不同组织病理学变异的病例。进行了一项回顾性病历审查，以查找2018年8月至2023年12月在印度北方邦巴雷利的罗希尔坎德癌症研究所接受手术的口腔鳞状细胞癌病例。为此检索了电子数据库，以病例系列的形式纳入了接受根治性手术（包括颈部清扫）且有或无辅助治疗的口腔鳞状细胞癌的组织病理学变异。记录并评估了组织病理学变异的临床病理细节。还尽可能记录了给予的治疗以及治疗后患者的状况。共确定了2018年8月至2023年12月在我院接受治疗的421例口腔鳞状细胞癌（OSCC）病例。其中，有408例（97%）为传统OSCC，其余13例（3.1%）为传统OSCC的罕见组织病理学变异，包括2例（0.5%）棘层松解性鳞状细胞癌（ASCC）、7例（1.7%）肉瘤样鳞状细胞癌（SSCC）和4例（1%）疣状鳞状细胞癌（VSCC）。尽管接受了以同步放化疗（CTRT）形式的辅助治疗，ASCC和SSCC的预后仍较差，而VSCC尽管未接受任何辅助治疗，预后却良好。SSCC和ASCC是高度侵袭性肿瘤，而VSCC预后良好。
