SARS-CoV-2 疫苗 mRNA1273 和 BNT162b2 的疗效和安全性可能因猖獗的 C 到 U RNA 编辑而变得复杂。
The efficacy and safety of SARS-CoV-2 vaccines mRNA1273 and BNT162b2 might be complicated by rampant C-to-U RNA editing.
机构信息
Department of Emergency Medicine, The Affiliated Hospital of Qingdao University, Qingdao, 266000, Shandong, China.
Department of Emergency Intensive Care Unit, The Affiliated Hospital of Qingdao University, Qingdao, 266000, Shandong, China.
出版信息
J Appl Genet. 2023 May;64(2):361-365. doi: 10.1007/s13353-023-00756-w. Epub 2023 Mar 21.
The SARS-CoV-2 RNA vaccines are smartly designed to increase the synonymous codon usage by introducing multiple U-to-C mutations. This design would elevate the translation efficiency of vaccine RNAs. However, we found evidence to reason that the designed cytidines might be converted to uridines again by C-to-U RNA deamination in host cells. This C-to-U mechanism might be a main factor that affects the efficacy and safety of RNA vaccines.
SARS-CoV-2 的 RNA 疫苗经过精心设计，通过引入多个 U 到 C 的突变来增加同义密码子的使用。这种设计可以提高疫苗 RNA 的翻译效率。然而，我们有证据表明，这些设计的胞嘧啶可能会在宿主细胞中再次被 C 到 U 的 RNA 脱氨酶转化为尿嘧啶。这种 C 到 U 的机制可能是影响 RNA 疫苗效力和安全性的主要因素。
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