Institute of Forensic Medicine, Hanover Medical School, Department of Legal Medicine, Carl-Neuberg-Straße 1, 30625, Hannover, Germany.
Forensic Sci Med Pathol. 2023 Jun;19(2):192-197. doi: 10.1007/s12024-023-00602-9. Epub 2023 Mar 21.
328 autopsy cases of fatal pulmonary thromboembolism (PE) were compared to 984 age- and sex-matched controls to evaluate the association between obesity and PE in a forensic context. Both PE and control cases had a mean age of 67,8 years (male 62,9 years, females 71,7 years). The percentage of morbidly obese persons with a body mass index (BMI) of above 40 or abdominal subcutaneous adipose tissue of above 4 cm was higher in the PE group (8,39% vs. 4,67% and 29.45% vs. 23.40%, respectively). On the other side, that of very slim persons (BMI below 18.5 or adipose tissue below 3 cm) was significantly smaller (4,27% vs. 7,52% and 47.55% vs. 56,60%). We thus found a strong association between being overweight and death from PE, while slim persons seem to be at an advantage. As the group of underweight persons includes those suffering from chronic diseases with reduced mobility or hypercoagulability (e.g. tumor kachexia or sarkopenia due to immobilisation), this finding is to some extent unexpected.
将 328 例致命性肺血栓栓塞症（PE）的尸检案例与 984 例年龄和性别匹配的对照进行比较，以评估肥胖与法医背景下的 PE 之间的关联。PE 组和对照组的平均年龄均为 67.8 岁（男性 62.9 岁，女性 71.7 岁）。病态肥胖者（BMI 大于 40 或腹部皮下脂肪组织大于 4cm）的百分比在 PE 组中更高（8.39%比 4.67%和 29.45%比 23.40%）。另一方面，非常消瘦者（BMI 低于 18.5 或脂肪组织低于 3cm）的比例明显较小（4.27%比 7.52%和 47.55%比 56.60%）。因此，我们发现超重与 PE 死亡之间存在很强的关联，而消瘦者似乎处于优势地位。由于体重不足者包括因慢性疾病导致活动能力下降或高凝状态（例如因固定而导致的肿瘤恶病质或肌肉减少症）的人，因此这一发现在某种程度上是出乎意料的。
