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一名肝细胞癌患者经皮射频消融术后发生腹膜内出血的病例。

A case of hemoperitoneum after percutaneous radiofrequency ablation in a patient with hepatocellular carcinoma.

作者信息

Ishigami Akiko, Inaka Shogo, Ishida Yuko, Nosaka Mizuho, Kuninaka Yumi, Yamamoto Hiroki, Shimada Emi, Kimura Akihiko, Furukawa Fukumi, Kondo Toshikazu

机构信息

Department of Forensic Medicine, Wakayama Medical University, Kimiidera 811-1, Wakayama, 641-8509, Japan.

出版信息

Forensic Sci Med Pathol. 2024 Mar;20(1):189-193. doi: 10.1007/s12024-023-00601-w. Epub 2023 Mar 21.

Abstract

We report a case of hemoperitoneum after percutaneous radiofrequency ablation in a patient with hepatocellular carcinoma. A 60-year-old female was hospitalized for the treatment of thrombasthenia and cirrhosis caused by chronic Hepatitis C, and computed tomography revealed hepatocellular carcinoma, which was treated by percutaneous radiofrequency ablation. After the ablation, hemoperitoneum was suspected because of the low hemoglobin level with abdominal pain. Approximately 6 h after the ablation treatment, the patient suddenly fell into a shock state and died. In this case, medical treatment-related death including malpractice was suspected, and forensic autopsy was performed. The abdominal cavity contained 910 mL of dark red fluid blood and 210 g of soft hemocoagula. Moreover, several puncture marks were observed on the liver surface and diaphragm, and there was no clear damage to the main arteries and veins. Considering the macroscopic and microscopic findings, the cause of death was assumed as hemorrhagic shock due to the hemoperitoneum caused by the damage to the liver by radiofrequency ablation. It is important to consider all the indications and adverse effects of radiofrequency ablation.

摘要

我们报告了一例肝细胞癌患者经皮射频消融术后发生腹腔积血的病例。一名60岁女性因慢性丙型肝炎导致血小板无力症和肝硬化而住院治疗,计算机断层扫描显示为肝细胞癌,遂接受经皮射频消融治疗。消融术后,因血红蛋白水平降低且伴有腹痛,怀疑发生了腹腔积血。消融治疗约6小时后,患者突然陷入休克状态并死亡。在该病例中,怀疑存在包括医疗事故在内的与治疗相关的死亡情况,遂进行了法医尸检。腹腔内有910毫升暗红色血性液体和210克软性血凝块。此外,在肝脏表面和膈肌上观察到多个穿刺痕迹,主要动静脉无明显损伤。综合宏观和微观检查结果,推测死亡原因是射频消融对肝脏造成损伤导致腹腔积血,进而引发失血性休克。考虑射频消融的所有适应证和不良反应非常重要。

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