McMillan J J, Vreman H J, Stevenson D K
Department of Pediatrics, Stanford University School of Medicine, CA 94305.
J Pediatr Gastroenterol Nutr. 1987 Sep-Oct;6(5):795-8. doi: 10.1097/00005176-198709000-00024.
The excretion rate of CO (VeCO), an index of total bilirubin production, and the total plasma bilirubin level are significantly elevated by 72 h after ligation of the common bile duct in adult male Wistar rats. At 72 and 96 h, rats prepared in this manner were subcutaneously injected with 50 mumol/kg body weight of tin-protoporphyrin IX (TP) (n = 5) or saline (n = 6). At 120 h after surgery, the VeCO had fallen from the pretreatment level in the TP-treated animals by 22% (P less than 0.025) compared with no significant change in the saline-treated controls. The plasma total bilirubin level of the experimental animals had also declined by 32% (p less than 0.0005) compared with their pretreatment level. The hyperbilirubinemia of the saline-treated controls was not significantly modified. These results suggest that TP reduces bilirubin production and plasma total bilirubin levels in adult rats with surgically created obstructive jaundice.
作为总胆红素生成指标的一氧化碳排泄率（VeCO）以及血浆总胆红素水平，在成年雄性Wistar大鼠胆总管结扎后72小时显著升高。在72小时和96小时时，以这种方式制备的大鼠皮下注射50微摩尔/千克体重的锡原卟啉IX（TP）（n = 5）或生理盐水（n = 6）。术后120小时，与生理盐水处理的对照组无显著变化相比，TP处理动物的VeCO较预处理水平下降了22%（P < 0.025）。实验动物的血浆总胆红素水平较预处理水平也下降了32%（P < 0.0005）。生理盐水处理对照组的高胆红素血症未得到显著改善。这些结果表明，TP可降低手术造成梗阻性黄疸成年大鼠的胆红素生成及血浆总胆红素水平。
