Stevenson D K, Salomon W L, Moore L Y, Trudgen J K, Cowan B E, Vreman H J, Kwong L K
J Pediatr Gastroenterol Nutr. 1984 Nov;3(5):790-4. doi: 10.1097/00005176-198411000-00026.
Total bilirubin formation (TBF) in the rat after a short period of common bile duct ligation was studied by measuring the pulmonary excretion rate of CO (VECO). At postoperative day 3, the VECO of experimental animals was higher when compared with the preoperative VECO (p less than 0.005); whereas the VECO of control animals did not change. Also, on the 3rd postoperative day, the relative rate of early labeling of bilirubin following the administration of delta-aminolevulinic acid-5-14C, a preferential hepatic heme synthesis precursor, was similar between the experimental and control animals; only the experimental animals had an abnormal peroxide hemolysis test. We conclude that common bile duct ligation in the rat is associated with elevations in the VECO, indicating significant increases in TBF, and the source of the increase is probably of erythropoietic origin. This finding may be relevant to the understanding of the pathophysiology of obstructive jaundice in human neonates.
通过测量一氧化碳的肺排泄率（VECO），研究了大鼠短期胆总管结扎后的总胆红素生成（TBF）情况。术后第3天，与术前的VECO相比，实验动物的VECO更高（p < 0.005）；而对照动物的VECO没有变化。此外，在术后第3天，给予δ-氨基乙酰丙酸-5-14C（一种优先的肝血红素合成前体）后胆红素的早期标记相对率在实验动物和对照动物之间相似；只有实验动物的过氧化物溶血试验异常。我们得出结论，大鼠胆总管结扎与VECO升高有关，表明TBF显著增加，且增加的来源可能是造血源性的。这一发现可能与理解人类新生儿阻塞性黄疸的病理生理学有关。
