Department of Pediatrics, AIIMS, Raipur, India.
Division of Pediatric Critical Care, Department of Pediatrics, AIIMS, Raipur, India.
Indian J Pediatr. 2023 Sep;90(9):934-936. doi: 10.1007/s12098-023-04552-6. Epub 2023 Mar 22.
This ambispective observational study, was conducted at a tertiary care centre in Central India. Children aged <16 y who tested positive for SARS-CoV2 between 1st April 2020 to 30th April 2022 were included. The prevalence of coronavirus disease-19 (COVID-19) infection was 1.2%. Of 525 children, median age was 60 mo; 88 (16.7%) were infants. Comorbidities were noted in 89 (16.9%) children. About 59% (n=309) were asymptomatic. Among symptomatic (n=216) children, fever (57.9%) was the most common symptom followed by cough (37%), running nose (21.3%) and shortness of breath (13.9%). Forty-three (8.2%) children required pediatric intensive care unit (PICU) admission, among which 21 required invasive ventilation. Patients with comorbidities were independently associated with need for invasive mechanical ventilation. Among PICU admitted children, 20 patients died. In multivariate logistic regression, children presenting with fever, shortness of breath and vasoactive requirement were found to be significantly associated with mortality. As the number of waves progressed, number of admissions were less but severity, association with comorbidities, need of ICU, mechanical ventilation and death rate increased.
本前瞻性观察研究在印度中部的一家三级护理中心进行。纳入了 2020 年 4 月 1 日至 2022 年 4 月 30 日期间 SARS-CoV2 检测呈阳性的 <16 岁儿童。新冠肺炎（COVID-19）感染的患病率为 1.2%。在 525 名儿童中，中位数年龄为 60 个月；88 名（16.7%）为婴儿。89 名（16.9%）儿童有合并症。约 59%（n=309）为无症状。在有症状（n=216）儿童中，发热（57.9%）是最常见的症状，其次是咳嗽（37%）、流鼻涕（21.3%）和呼吸急促（13.9%）。43 名（8.2%）儿童需要入住儿科重症监护病房（PICU），其中 21 名需要有创通气。有合并症的患者与需要有创机械通气独立相关。在入住 PICU 的儿童中，有 20 名死亡。在多变量逻辑回归中，发热、呼吸急促和血管活性药物需求的儿童与死亡率显著相关。随着波数的增加，住院人数减少，但严重程度、与合并症的关系、入住 ICU、机械通气和死亡率都有所增加。
