Jung Youn Joo, Lee Seungju, Kim Hyun Yul, Paik Hyun-June, Jung Chang Shin, Kim Jee Yeon, Jung Hyuk Jae, Lee Seokwon, Kim Choongrak
Department of Surgery, Pusan National University Yangsan Hospital, Pusan National University School of Medicine, Yangsan, Korea.
Department of Pathology, Pusan National University Yangsan Hospital, Pusan National University School of Medicine, Yangsan, Korea.
Korean J Clin Oncol. 2020 Jun;16(1):52-56. doi: 10.14216/kjco.20009. Epub 2020 Jun 30.
As we enter an aging society, the number of elderly patients with breast cancer is increasing. We assessed the prognostic factors for breast cancer recurrence or metastasis in patients over the age of 65 years by analyzing tumor characteristics and long-term clinical outcomes.
In this retrospective study, the data of 286 breast cancer patients aged 65 years and older, who underwent treatment at the Pusan National University Hospital and Pusan National University Yangsan Hospital from 2008 to 2014, were analyzed. The patients were divided into two groups: those with recurrence or metastasis and those without. Cox-regression model was used to analyze the risk factors for recurrence or metastasis. Kaplan-Meier method was used to analyze survival rates by the log-rank test.
Among the 286 patients with invasive breast cancer, 43 patients (15.0%) had recurrence or distant metastasis during a median follow-up period of 61 months. Advanced stages of breast cancer and patients who are not adapted to endocrine therapy were associated with poor prognosis.
In this study, advanced stages of breast cancer and endocrine therapy were the prognostic factors for breast cancer recurrences or metastases. Early detection of elderly breast cancer generally increases the possibility of diagnosis at an earlier stage, which can lead to a better prognosis. Moreover, endocrine therapy should be administered to elderly patients who manifest favorable intrinsic subtypes of breast cancer.
随着我们步入老龄化社会，老年乳腺癌患者的数量正在增加。我们通过分析肿瘤特征和长期临床结果，评估了65岁以上乳腺癌患者复发或转移的预后因素。
在这项回顾性研究中，分析了2008年至2014年在釜山国立大学医院和釜山国立大学梁山医院接受治疗的286例65岁及以上乳腺癌患者的数据。患者分为两组：复发或转移组和未复发或转移组。采用Cox回归模型分析复发或转移的危险因素。采用Kaplan-Meier法通过对数秩检验分析生存率。
在286例浸润性乳腺癌患者中，43例（15.0%）在中位随访期61个月期间出现复发或远处转移。乳腺癌晚期以及不适合内分泌治疗的患者预后较差。
在本研究中，乳腺癌晚期和内分泌治疗是乳腺癌复发或转移的预后因素。老年乳腺癌的早期发现通常会增加早期诊断的可能性，从而带来更好的预后。此外，对于表现出有利的乳腺癌内在亚型的老年患者，应给予内分泌治疗。
