Kang Ayoung, Cho Sung Hwan, Park Byung-Soo, Son Gyung Mo, Kim Hyun Sung, Kim Jae-Joon, Kim Su Jin, Shin Dong Hoon, Kim Tae Un
Department of General Surgery, Pusan National University Yangsan Hospital, Yangsan, Korea.
Internal Medicine, Pusan National University Yangsan Hospital, Yangsan, Korea.
Korean J Clin Oncol. 2020 Dec;16(2):138-141. doi: 10.14216/kjco.20021. Epub 2020 Dec 31.
An extragastrointestinal stromal tumor (EGIST) is a gastrointestinal stromal tumor that arises outside of the gastrointestinal tract. Most EGISTs are located in the omentum, mesentery, and retroperitoneum. The occurrence of an EGIST at the perianal region is very rare. Herein, we report our experience with EGISTs in the perianal area and review the literature. A 70-year-old man presented to our hospital with a 2-year history of anal discomfort. A pelvic magnetic resonance imaging scan showed a homogenous, well-defined, soft tissue density mass. The patient underwent mass excision, and the pathological examination confirmed that the mass was an EGIST. The size of the tumor was 4.3×3.2 cm, and the mitotic count was 1 per 50 high-power fields. The tumor cells were immunohistochemically positive for KIT and CD34 but were negative for S-100 and alpha-smooth muscle actin. There were no other abnormal findings in the gastrointestinal tract; upon pathological review, this case was confirmed as perianal EGIST. Therefore, EGIST should be considered as a differential diagnosis of perianal masses.
胃肠道外间质瘤（EGIST）是一种起源于胃肠道外的胃肠道间质瘤。大多数EGIST位于大网膜、肠系膜和腹膜后。EGIST发生于肛周区域非常罕见。在此，我们报告我们在肛周区域EGIST方面的经验并复习文献。一名70岁男性因肛门不适2年就诊于我院。盆腔磁共振成像扫描显示一个均匀、边界清晰的软组织密度肿块。患者接受了肿块切除术，病理检查证实该肿块为EGIST。肿瘤大小为4.3×3.2 cm，每50个高倍视野有1个核分裂象。肿瘤细胞免疫组化KIT和CD34呈阳性，但S-100和α-平滑肌肌动蛋白呈阴性。胃肠道无其他异常发现；经病理复查，该病例确诊为肛周EGIST。因此，EGIST应被视为肛周肿块的鉴别诊断之一。
