Department of Radiology, The Third Affiliated Hospital of Soochow University, Changzhou 213003, P. R. China.
Center for Molecular Imaging and Nuclear Medicine, State Key Laboratory of Radiation Medicine and Protection, School for Radiological and Interdisciplinary Sciences (RAD-X), Suzhou Medical College of Soochow University, Collaborative Innovation Center of Radiation Medicine of Jiangsu Higher Education Institutions, Suzhou 215123, P. R. China.
ACS Appl Mater Interfaces. 2023 Apr 5;15(13):16460-16470. doi: 10.1021/acsami.3c00052. Epub 2023 Mar 22.
Excess reactive oxygen species (ROS) can induce serious acute kidney injury (AKI) to result in numerous deaths annually in clinical practice. Elimination of excess ROS by advanced nanotechnology is a very promising AKI therapy. In this Article, we report that PVP-stabilized and quercetin-functionalized ultrasmall CuSe nanoparticles (abbreviated as CSPQ NPs) can efficiently scavenge ROS and increase the expression of intracellular antioxidative enzymes by activating the nuclear factor erythroid 2-related factor 2 (Nrf2) protein, which drastically alleviates the cellular oxidative stress. Our ultrasmall nanoparticles exhibit excellent biocompatibility. They can be rapidly accumulated into the injured kidney to simultaneously eliminate ROS and activate Nrf2 to improve the renal function. This work demonstrates the great potential of simultaneous elimination of ROS and activation of intracellular Nrf2 in treatment of AKI. It also highlights the potential of CSPQ NPs in protection and prevention of AKI.
过量的活性氧（ROS）会导致严重的急性肾损伤（AKI），每年在临床实践中都会导致大量死亡。通过先进的纳米技术消除过量的 ROS 是一种很有前途的 AKI 治疗方法。在本文中，我们报告了 PVP 稳定和槲皮素功能化的超小 CuSe 纳米颗粒（简称 CSPQ NPs）可以通过激活核因子红细胞 2 相关因子 2（Nrf2）蛋白来有效清除 ROS 并增加细胞内抗氧化酶的表达，从而大大减轻细胞氧化应激。我们的超小纳米颗粒具有优异的生物相容性。它们可以迅速积聚到受损的肾脏中，同时清除 ROS 并激活 Nrf2 以改善肾功能。这项工作证明了同时消除 ROS 和激活细胞内 Nrf2 在 AKI 治疗中的巨大潜力。它还突出了 CSPQ NPs 在 AKI 的保护和预防中的潜力。
