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[脑蛋白水解物治疗认知障碍]

[Cerebrolysin in the treatment of cognitive impairment].

作者信息

Bogolepova A N

机构信息

Pirogov Russian National Research Medical University, Moscow, Russia.

Federal Center of Brain and Neurotechnologies, Moscow, Russia.

出版信息

Zh Nevrol Psikhiatr Im S S Korsakova. 2023;123(3):20-25. doi: 10.17116/jnevro202312303120.

Abstract

Cognitive impairment is one of the most important problems of modern health care. Currently, according to WHO, more than 55 million people worldwide are living with dementia. Dementia is one of the leading causes of disability and addiction among older people worldwide. Even more significant is the number of patients with mild cognitive impairment who have an increased risk of progression to dementia compared to people of the same age without cognitive impairment. The number of patients with cognitive impairment has also increased due to the consequences of COVID-19. It is necessary to use drugs that not only improve cognitive functions, but also slow down their progression. One of these drugs is cerebrolysin, the effectiveness of which has been confirmed in various types of cognitive impairment. Cerebrolysin, being a preparation from the brain of a pig, belongs to the group of biological drugs. In the production of Cerebrolysin very strict measures are taken to comply with the technology, which ensures the quality and identity of the product from batch to batch. The experience of many years of clinical use of Cerebrolysin testifies not only to its high efficiency, but also to its safety. It should be taken into account that similar substances can be developed in relation to biological products - biosimilars or biosimilars, which can be considered comparable only in case of equivalent pharmacokinetic parameters, efficacy and safety.

摘要

认知障碍是现代医疗保健最重要的问题之一。目前,据世界卫生组织统计,全球有超过5500万人患有痴呆症。痴呆症是全球老年人残疾和失能的主要原因之一。更值得注意的是,与无认知障碍的同龄人相比,轻度认知障碍患者发展为痴呆症的风险更高。由于新冠疫情的影响,认知障碍患者的数量也有所增加。有必要使用不仅能改善认知功能,还能减缓其进展的药物。其中一种药物是脑蛋白水解物,其有效性已在各种类型的认知障碍中得到证实。脑蛋白水解物是一种源自猪脑的制剂,属于生物药物类别。在脑蛋白水解物的生产过程中,采取了非常严格的措施来遵守工艺要求,这确保了产品批次间的质量和一致性。多年来脑蛋白水解物的临床使用经验不仅证明了其高效性,还证明了其安全性。应该考虑到,对于生物制品可能会开发出类似物质——生物仿制药或生物类似药,只有在药代动力学参数、疗效和安全性相当的情况下,才能认为它们具有可比性。

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