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[认知障碍与使用药物脑蛋白水解物的策略。国际专家委员会决议(2023年5月12日)]

[Cognitive impairment and tactics of using the drug Cerebrolysin. Resolution of the International Council of Experts (May 12, 2023)].

作者信息

Levin O S, Voznyuk I A, Illarioshkin S N, Tkacheva O N, Bogolepova A N, Vasenina E E, Gavrilova S I, Dokukina T V, Emelin A Y, Lobzin V Y, Mkhitaryan E A, Khatkova S E, Yakushin M A, Yanishevskiy S N

机构信息

Russian Medical Academy of Continuing Professional Education, Moscow, Russia.

Pavlov First Saint Petersburg State Medical University, St. Petersburg, Russia.

出版信息

Zh Nevrol Psikhiatr Im S S Korsakova. 2023;123(9):121-130. doi: 10.17116/jnevro2023123091121.

Abstract

The aging of the population and the associated increase in the share of cognitive impairments in the structure of a wide range of diseases are a serious challenge for modern healthcare. Difficulties in the treatment of cognitive disorders are determined by many factors, including the age of patients, comorbidity, forced polypragmasia and the adequacy of the dosage of drugs that restore cognitive activity. The experts discussed information about the therapeutic potential of the drug Cerebrolysin in the treatment of cognitive disorders of various origins, stated significant experience of its effective and safe use in many clinical studies in mild and moderate forms of dementia. At the same time, there was a lack of consistent and systematic data on the dosage regimen, frequency, and duration of use of the drug in different forms of cognitive impairment and the degree of their severity. The aim of the international council of experts was to determine the optimal dosage regimens of the drug Cerebrolysin in patients with various etiologies and severity of cognitive impairment. The result of the work was the approval of a unified scheme for the use of the drug Cerebrolysin, considering the severity of the disease and its duration.

摘要

人口老龄化以及各类疾病结构中认知障碍所占比例的相应增加,是现代医疗保健面临的严峻挑战。认知障碍治疗的困难由多种因素决定,包括患者年龄、合并症、被迫使用多种药物以及恢复认知活动药物剂量的适当性。专家们讨论了关于药物脑蛋白水解物治疗各种病因引起的认知障碍的治疗潜力的信息,指出了其在轻度和中度痴呆症的许多临床研究中有效且安全使用的大量经验。与此同时,对于该药物在不同形式认知障碍及其严重程度下的给药方案、使用频率和持续时间,缺乏一致且系统的数据。国际专家委员会的目的是确定脑蛋白水解物在患有各种病因和不同严重程度认知障碍患者中的最佳给药方案。这项工作的结果是批准了一项考虑疾病严重程度及其持续时间的脑蛋白水解物统一用药方案。

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