Ahmadinejad Izadmehr, Mardasi Kimia Ghanbari, Ahmadinejad Yasmina, Kahrizi Mohammad Saeed, Soltanian Ali, Merdasi Pooriya Ghanbari, Ahmadinejad Mojtaba
Medical Student, Students' Scientific Research Center, Tehran University of Medical Science, Tehran, Iran.
Student of Research Committee, Alborz University of Medical Sciences, Karaj, Iran.
Curr Med Imaging. 2023 Mar 22. doi: 10.2174/1573405619666230322095526.
Thyroid nodules are one of the most common clinical findings, with a prevalence of 68% in adults. Thyroid cancer is the fifth most common cancer in women.
The purpose of this study is to evaluate the diagnostic efficacy of Thyroid Imaging Reporting and Data Systems proposed by the American College of Radiology (ACR-TIRADS) for the diagnosis of malignancy in surgically resected thyroid nodules.
In this retrospective study, patients who underwent thyroid nodules resected surgically from 2018-2020 were included. Before resection, an ultrasound was performed for TIRADS scores, and after resection histopathology, thyroid mass was obtained. The outcomes of the two systems were statistically compared.
The mean age of the 146 included patients was 47.6 ± 14.08 years, of which 109 (74.7%) were female. Based on TIRADS, 47 patients (32.2%) were in TI-RADS TR3, 36 patients (24.7%) were in TIRADS TR2, 34 (23.3%) in TIRADS 4, 24 (16.4%) in TIRADS TR5 and 5 patients (3.4%) were in TIRADS TR1. The overall sensitivity was 79.9% when ACR-TIRADS TR4 was set as a diagnostic cutoff value. Considering the total of TIRADS TR4 and TIRADS TR5 as predictors of thyroid malignancy, the sensitivity was 74.5% and the specificity was 76.8%. The positive and negative predictive value was 60.3% and 76.8%.
ACR-TIRADS 4 and 5 can be considered good predictors of malignancy in thyroid nodules. More studies, including larger samples, are required to obtain a better conclusion.
甲状腺结节是最常见的临床发现之一，在成年人中的患病率为68%。甲状腺癌是女性中第五大常见癌症。
本研究的目的是评估美国放射学会提出的甲状腺影像报告和数据系统（ACR-TIRADS）对手术切除的甲状腺结节恶性肿瘤诊断的有效性。
在这项回顾性研究中，纳入了2018年至2020年接受甲状腺结节手术切除的患者。在切除前，进行超声检查以获得TIRADS评分，切除后进行组织病理学检查以获取甲状腺肿块。对这两种系统的结果进行统计学比较。
纳入的146例患者的平均年龄为47.6±14.08岁，其中109例（74.7%）为女性。根据TIRADS，47例患者（32.2%）为TI-RADS TR3，36例患者（24.7%）为TIRADS TR2，34例（23.3%）为TIRADS 4，24例（16.4%）为TIRADS TR5，5例患者（3.4%）为TIRADS TR1。当将ACR-TIRADS TR4设定为诊断临界值时，总体敏感性为79.9%。将TIRADS TR4和TIRADS TR5的总和视为甲状腺恶性肿瘤的预测指标时，敏感性为74.5%，特异性为76.8%。阳性和阴性预测值分别为60.3%和76.8%。
ACR-TIRADS 4和5可被视为甲状腺结节恶性肿瘤的良好预测指标。需要更多研究，包括更大样本量的研究，以得出更好的结论。
