左心耳容积预测射频导管消融术后心房颤动复发：一项荟萃分析。
Left Atrial Appendage Volume Predicts Atrial Fibrillation Recurrence after Radiofrequency Catheter Ablation: A Meta-Analysis.
机构信息
Department of Cardiology, Dushu Lake Hospital Affiliated to Soochow University, Medical Center of Soochow University , Suzhou Dushu Lake Hospital , Suzhou - China.
Institution for Hypertension of Soochow University , Suzhou - China.
出版信息
Arq Bras Cardiol. 2023 Mar;120(3):e20220471. doi: 10.36660/abc.20220471.
BACKGROUND
The influence of left atrial appendage volume (LAAV) on the recurrence of atrial fibrillation (AF) following radiofrequency catheter ablation remains unclear.
OBJECTIVES
We performed a meta-analysis to assess whether LAAV is an independent predictor of AF recurrence following radiofrequency catheter ablation.
METHODS
The PubMed and the Cochrane Library databases were searched until March 2022 to identify publications evaluating LAAV in association with AF recurrence after radiofrequency catheter ablation. Seven studies that fulfilled the specified criteria of our analysis were found. We used the Newcastle-Ottawa Scale to evaluate the quality of the studies. The pooled effects were evaluated depending on standardized mean differences (SMDs) or hazard ratios (HRs) with 95% confidence intervals (CIs). P values < 0.05 were considered statistically significant.
RESULTS
A total of 1017 patients from 7 cohort studies with a mean follow-up 16.3 months were included in the meta-analysis. Data from 6 studies (943 subjects) comparing LAAV showed that the baseline LAAV was significantly higher in patients with AF recurrence compared to those without AF (SMD: -0.63; 95% CI: -0.89 to -0,37; all p values < 0.05; I2= 62.6%). Moreover, higher LAAV was independently associated with a significantly higher risk of AF recurrence after radiofrequency catheter ablation (HR: 1.10; 95% CI: 1.02 to 1.18).
CONCLUSIONS
The meta-analysis showed that there is a significant correlation between LAAV and AF recurrence after radiofrequency catheter ablation, and the role of LAAV in AF patients should not be ignored in clinical practice.
背景
左心耳容积（LAAV）对射频导管消融后心房颤动（AF）复发的影响尚不清楚。
目的
我们进行了一项荟萃分析，以评估 LAAV 是否是射频导管消融后 AF 复发的独立预测因子。
方法
我们检索了 PubMed 和 Cochrane 图书馆数据库，直到 2022 年 3 月，以确定评估射频导管消融后 LAAV 与 AF 复发相关的出版物。我们找到了符合我们分析标准的 7 项研究。我们使用纽卡斯尔-渥太华量表来评估研究的质量。根据标准化均数差（SMD）或风险比（HR）及其 95%置信区间（CI）评估汇总效应。P 值 < 0.05 被认为具有统计学意义。
结果
共有 7 项队列研究的 1017 名患者纳入荟萃分析，平均随访 16.3 个月。比较 LAAV 的 6 项研究（943 例患者）的数据显示，AF 复发患者的 LAAV 基线明显高于无 AF 复发患者（SMD：-0.63；95%CI：-0.89 至-0.37；所有 P 值均<0.05；I2=62.6%）。此外，较高的 LAAV 与射频导管消融后 AF 复发的风险显著增加独立相关（HR：1.10；95%CI：1.02 至 1.18）。
结论
荟萃分析表明，LAAV 与射频导管消融后 AF 复发之间存在显著相关性，在临床实践中不应忽视 LAAV 在 AF 患者中的作用。
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