Verhoeven W M, van Praag H M, van Ree J M, de Wied D
Arch Gen Psychiatry. 1979 Mar;36(3):294-8. doi: 10.1001/archpsyc.1979.01780030060005.
It was postulated from animal experiments that gamma-endorphin and, in particular, the nonopiate-like peptide [des-Tyr1]-gamma-endorphin (DTgammaE, beta-lipotropin [beta-LPH]62-77) have neurolepic-like activity. To test this, 14 patients with long-lasting, relapsing schizophrenic or schizoaffective psychosis resistant to conventional neuroleptics were treated with DTgammaE. An open design was used first for six patients (study 1) and a double-blind, crossover design for the other eight (study 2). In study 1, all neuroleptic medication was discontinued and 1 mg of DTgammaE zinc phosphate was given daily intramuscularly for about seven days. In study 2, six patients were maintained with neuroleptic therapy and two patients were drug free; all eight received daily intramuscular injections of 1 mg of nonlasting DTgammaE in saline and solution for eight days. There was transient or semipermanent improvement in both studies in which the psychotic symptoms diminished or even disappeared. In study 2, there was a slight but significant improvement with the first treatment. Improvement continued and by day 4, the psychotic symptoms had almost disappeared. No toxic side effects were noted. These effects of DTgammaE may be a consequence of the normalization of beta-endorphin homeostasis in the brain.
动物实验推测γ-内啡肽，尤其是非阿片样肽[去酪氨酸1]-γ-内啡肽（DTγE，β-促脂素[β-LPH]62-77）具有类神经安定活性。为验证此推测，对14例对传统抗精神病药物耐药的慢性复发性精神分裂症或分裂情感性精神病患者使用DTγE进行治疗。首先对6例患者采用开放设计（研究1），对另外8例采用双盲交叉设计（研究2）。在研究1中，停用所有抗精神病药物，每日肌肉注射1mg磷酸锌DTγE，持续约7天。在研究2中，6例患者维持抗精神病治疗，2例未用药；所有8例患者每日肌肉注射1mg溶于生理盐水的非长效DTγE，持续8天。两项研究中均出现了短暂或半永久性改善，精神病症状减轻甚至消失。在研究2中，首次治疗时有轻微但显著的改善。改善持续，到第4天时，精神病症状几乎消失。未观察到毒性副作用。DTγE的这些作用可能是大脑中β-内啡肽内稳态恢复正常的结果。
