硒作为中年女性代谢综合征的预测因子。

Selenium as a predictor of metabolic syndrome in middle age women.

机构信息

Department of Nursing, Pomeranian Medical University in Szczecin, Szczecin 71-210, Poland.

Department of Animal Reproduction Biotechnology and Environmental Hygiene, West Pomeranian University of Technology, Szczecin 71-217, Poland.

出版信息

Aging (Albany NY). 2023 Mar 21;15(6):1734-1747. doi: 10.18632/aging.204590.

DOI:10.18632/aging.204590

PMID:36947700

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10085601/

Abstract

BACKGROUND

Selenium plays an important role in metabolic homeostasis. It has been suggested that it may also affect the expression and activity of PPAR-γ. The aim of study was to analyze the relationships between these variables in the context of the health of women, for whom the risk of MetS increases with age.

MATERIAL AND METHODS

The study involved 390 women in middle age. The stages of study: a survey-based part; anthropometric measurements; analysis of biological material (blood) in terms of glycemia, triglyceride, HDL, and selenium levels, as well as genetic analysis of the PPAR-γ polymorphisms.

RESULTS

It was found that selenium may moderate the effect of the G allele of the PPAR-γ gene on the occurrence of elevated waist circumference (OR=1.030, 95%CI 1.005-1.057, p=0.020); and the effect of the C (OR=1.077, 95%CI 1.009-1.149, p=0.026) and the G alleles (OR=1.052, 95%CI 1.025-1.080, p<0.000) on the odds of elevated blood pressure. Women in whom HDL levels were not significantly reduced, had higher selenium levels (p=0.007).

CONCLUSIONS

The effect of selenium on MetS and its components has not been demonstrated. 2. The effect of individual alleles of the PPAR-γ gene on MetS and its components was not demonstrated. 3. The concentration of selenium may affect waist circumference in carriers of the G allele, and arterial hypertension in carriers of the C and G alleles by affecting the expression of PPAR-γ. 4. Higher selenium concentrations increased the odds of higher HDL levels in the group of subjects meeting the MetS criteria.

摘要

背景

硒在代谢稳态中起着重要作用。有人认为它也可能影响 PPAR-γ 的表达和活性。本研究的目的是在女性健康背景下分析这些变量之间的关系，因为女性随着年龄的增长患代谢综合征的风险增加。

材料和方法

该研究涉及 390 名中年女性。研究阶段：基于调查的部分；人体测量学测量；分析血糖、甘油三酯、HDL 和硒水平的生物材料以及 PPAR-γ 基因多态性的遗传分析。

结果

发现硒可能调节 PPAR-γ 基因 G 等位基因对腰围升高发生的影响（OR=1.030，95%CI 1.005-1.057，p=0.020）；C（OR=1.077，95%CI 1.009-1.149，p=0.026）和 G 等位基因（OR=1.052，95%CI 1.025-1.080，p<0.000）对血压升高的几率的影响。高密度脂蛋白水平没有明显降低的女性，硒水平较高（p=0.007）。

结论

硒对代谢综合征及其成分的影响尚未得到证实。2. 个体 PPAR-γ 基因等位基因对代谢综合征及其成分的影响尚未得到证实。3. 硒的浓度可能通过影响 PPAR-γ 的表达，影响 G 等位基因携带者的腰围和 C 和 G 等位基因携带者的动脉高血压。4. 较高的硒浓度增加了符合代谢综合征标准的受试者中 HDL 水平较高的几率。