Sakata S
Dept. of Radiation Therapy, Chiba Cancer Center Hospital.
Gan No Rinsho. 1987 Oct;33(13):1532-41.
In radiation therapy, it is clearly recognized that the isoeffect dose of normal tissue decreases with the increase of the area or the volume of tissue irradiated, so that a marked change in therapeutic ratio occurs when large tumor is treated. This relationship has been called "volume effect" and several models such as power law relationship, volume dose histogram and integral probability have been developed to quantify the effect. Although the delivery of these models are based on clinical data, there is a wide variation between models and each model can be applied under restricted conditions. In order to develop reliable volume effect model theoretically and empirically, further studies with enough and suitable clinical data will be required.
在放射治疗中，人们清楚地认识到，正常组织的等效效应剂量会随着受照射组织面积或体积的增加而降低，因此在治疗大肿瘤时，治疗比会发生显著变化。这种关系被称为“体积效应”，并且已经开发了几种模型，如幂律关系、体积剂量直方图和积分概率模型来量化这种效应。尽管这些模型的推导是基于临床数据的，但模型之间存在很大差异，并且每个模型都只能在有限的条件下应用。为了从理论和经验上开发可靠的体积效应模型，将需要有足够且合适的临床数据进行进一步研究。
