Misonou J, Aizawa M, Nakamura S, Kanda M, Hishiyama H, Atsuta T
1st Dept. of Pathology, Hokkaido Univ. School of Med.
Gan No Rinsho. 1987 Nov;33(14):1833-8.
A rare autopsy case of a primary squamous cell carcinoma of the breast is reported. A 74-year-old Japanese woman, suffering from a left axillary nodule, underwent a radical mastectomy in May, 1986. The histopathological diagnosis had revealed a primary squamous cell carcinoma of the breast with a small area that indicated a solid tubular carcinoma. The patient, however, died four months later after a very rapid and aggressive metastasis of the tumor cells to her various organs. The autopsy revealed the presence of metastatic tumor cells in the systemic organs including the heart, lungs, liver, spleen, kidneys, pancreas, the bone marrow, and in the whole gastrointestinal tract. Histopathologically, the metastatic tumor cells in these organs were composed of squamous cell carcinoma solely, without tubular formation, showing a remarkable keratinization and mitotic activity. The histogenesis and the nature of the squamous cell carcinoma of the breast are briefly discussed.
报告了一例罕见的乳腺原发性鳞状细胞癌尸检病例。一名74岁的日本女性，因左腋窝结节，于1986年5月接受了根治性乳房切除术。组织病理学诊断显示为乳腺原发性鳞状细胞癌，有一小区域显示为实性管状癌。然而，患者在肿瘤细胞迅速且侵袭性地转移至其各个器官四个月后死亡。尸检发现全身各器官包括心脏、肺、肝脏、脾脏、肾脏、胰腺、骨髓以及整个胃肠道均存在转移性肿瘤细胞。组织病理学上，这些器官中的转移性肿瘤细胞仅由鳞状细胞癌组成，无管状结构形成，表现出明显的角化和有丝分裂活性。本文简要讨论了乳腺鳞状细胞癌的组织发生和性质。
